文献类型：期刊文献

英文题名：Functional magnetic resonance imaging studies in bipolar disorder in resting state: A coordinates-based meta-analysis

作者：Nan, Xia[1];Li, Wenling[2];Wang, Lin[3,4]

第一作者：Nan, Xia

通信作者：Wang, L[1];Wang, L[2]

机构：[1]Baiyin City Cent Hosp, Baiyin, Peoples R China;[2]2 Peoples Hosp Lanzhou, Lanzhou, Peoples R China;[3]Gansu Univ Chinese Med, Affiliated Hosp, Dept Radiol, Lanzhou, Peoples R China;[4]Canc Clin Med Res Ctr, Gansu Combinat Tradit Chinese & Western Med, Lanzhou, Peoples R China

第一机构：Baiyin City Cent Hosp, Baiyin, Peoples R China

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Affiliated Hosp, Dept Radiol, Lanzhou, Peoples R China;[2]corresponding author), Canc Clin Med Res Ctr, Gansu Combinat Tradit Chinese & Western Med, Lanzhou, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2024

卷号：344

外文期刊名：PSYCHIATRY RESEARCH-NEUROIMAGING

收录：;Scopus(收录号：2-s2.0-85201235226);WOS:【SCI-EXPANDED(收录号:WOS:001298624200001)】；

基金：This work was not supported by any funds.

语种：英文

外文关键词：Bipolar disorder; Amplitude of low-frequency fluctuation; Fractional amplitude of low-frequency fluctua-; tion; Regional homogeneity; Coordinate based meta-analysis

摘要：Exploring changes in the intrinsic activity of the brain in people with bipolar disorder (BD) is necessary. However, the findings have not yet led to consistent conclusions. In this regard, this paper aims to extract more obvious differential brain areas and neuroimaging markers, for the purpose of providing assistance for early clinical diagnosis and subsequent treatment. We conducted a meta-analysis of whole-brain resting-state functional magnetic resonance imaging (rs-fMRI) studies using seed-based d-mapping software that examined differences in amplitude of low-frequency fluctuations (ALFF), fractional amplitude of low-frequency fluctuations (fALFF), and regional homogeneity (ReHo) between patients with BD and healthy controls (HCs). Seed-based dMapping (formerly Signed Differential Mapping) ) with Permutation of Subject Images, or SDM-PSI, is a statistical technique for meta-analyzing studies of differences in brain activity or structure. A total of 16 articles involving 1112 individuals were included in this study for meta-analysis. This paper confidently analyzes the correlation between the clinical scales HAMD, HAMA, and YMRS, and the area of difference. We found significant changes that increased activation in the anterior connective and left lens nucleus, the nucleus of the shell, and BA 48 in BD patients compared with HC (P P < 0.05, uncorrected), as well as a significant correlation between HAMD and the left superior frontal gyrus (after FWE correction P < 0.05). Therefore, basal ganglia and frontal cortex may have important significance in the pathogenesis and pathological basis of BD, making it an important issue to be attached importance to.