文献类型：期刊文献

中文题名：中药调控相关信号通路促进腱骨愈合的研究进展

英文题名：Research progress of traditional Chinese medicine regulating related signaling pathways to promote tendonbone healing

作者：杨超强[1];汪小敏[2];王亮[3];王宜灿[1];康天泰[1];杨庆[1];舒洪旭[1];杨云云[1];张虎林[2]

第一作者：杨超强

机构：[1]甘肃中医药大学中医临床学院,兰州730030;[2]甘肃中医药大学附属医院北院骨科,兰州730030;[3]甘肃省中心医院骨科,兰州730070

第一机构：甘肃中医药大学中医临床学院

年份：2024

卷号：35

期号：6

起止页码：767

中文期刊名：中国药房

外文期刊名：China Pharmacy

收录：CSTPCD;;北大核心:【北大核心2023】；

基金：甘肃省自然科学基金项目(No.18JR3RA077);兰州市卫生健康科技发展项目(No.2019-050);兰州市人才创新创业项目(No.2020-RC-67);甘肃中医药大学附属医院院内课题(No.gzfy-2019-18)。

语种：中文

中文关键词：中药;腱骨愈合;信号通路;作用机制

外文关键词：traditional Chinese medicine;tendon-bone healing;signal pathway;mechanism of action

摘要：腱骨愈合是一种复杂的生物学过程,多条信号通路参与其中,如转化生长因子β信号通路、骨形态发生蛋白信号通路、Wnt信号通路、成纤维细胞生长因子信号通路、核因子κB信号通路等。本文总结了中药调控相关信号通路促进腱骨愈合的研究现状,发现多种中药单体或提取物(如黄芩素、淫羊藿苷、骨碎补总黄酮、小白菊内酯、三七总皂苷等)及中药复方(如桃红四物汤、六味地黄丸、续筋接骨液等)能够通过调节以上信号通路促进骨形成、抗炎、抗氧化等,进而有效促进腱骨愈合。
Tendon-bone healing is a complex biological process.Multiple signaling pathways are involved in tendon-bone healing,including transforming growth factor-βsignaling pathway,bone morphogenetic protein signaling pathway,Wnt signaling pathway,fibroblast growth factor signaling pathway and nuclear transcription factor-κB signaling pathway.This paper summarizes the research status of traditional Chinese medicine regulating related signaling pathways to promote tendon-bone healing.It is found that a variety of traditional Chinese medicine monomers or herbal extracts(such as baicalein,icariin,total flavonoids of Drynaria fortunei,parthenolide,total saponins of Panax notoginseng,etc.)and traditional Chinese medicine compounds(such as Taohong siwu decoction,Liuwei dihuang pill,Xujin jiegu liquid,etc.)can promote bone formation,anti-inflammatory,anti-oxidation,by regulating the above signaling pathways,thereby effectively promoting tendon-bone healing.