文献类型：期刊文献

英文题名：Isorhamnetin Promotes MKN-45 Gastric Cancer Cell Apoptosis by Inhibiting PI3K-Mediated Adaptive Autophagy in a Hypoxic Environment

作者：Li, Chenghao[1];Li, Jiawei[1];Li, Yan[1];Li, Ling[1];Luo, Yali[1];Li, Junjie[1];Zhang, Yiming[1];Wang, Yanru[1];Liu, Xiuzhu[1];Zhou, Xiaotian[1];Gong, Hongxia[1];Jin, Xiaojie[1,3];Liu, Yongqi[1,2]

第一作者：Li, Chenghao

通信作者：Jin, XJ[1];Liu, YQ[1];Liu, YQ[2];Jin, XJ[3]

机构：[1]Gansu Univ Chinese Med, Gansu Univ Key Lab Mol Med & Chinese Med Prevent, Lanzhou 730000, Gansu, Peoples R China;[2]Minist Educ, Key Lab Dun Huang Med & Transformat, Lanzhou 730000, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Coll Pharm, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Gansu Univ Key Lab Mol Med & Chinese Med Prevent, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Minist Educ, Key Lab Dun Huang Med & Transformat, Lanzhou 730000, Gansu, Peoples R China;[3]corresponding author), Gansu Univ Chinese Med, Coll Pharm, Lanzhou 730000, Peoples R China.|[1073501e14fb35863569f]甘肃中医药大学药学院（西北中藏药协同创新中心办公室）;[10735]甘肃中医药大学;

年份：2021

卷号：69

期号：29

起止页码：8130

外文期刊名：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

收录：;EI(收录号：20213110704211);Scopus(收录号：2-s2.0-85111511455);WOS:【SCI-EXPANDED(收录号:WOS:000679919400007)】；

基金：This study was supported by the National Natural Science Foundation of China (No.81960869), Provincial University Industry Support Project in Gansu (2020C-15), and Provincial Key Talent Project (GZT2020-9-1). Basic Research Innovation Group in Gansu (20JR10RA332).

语种：英文

外文关键词：isorhamnetin; apoptosis; autophagy; PI3K; gastric cancer

摘要：A tumor-related hypoxic microenvironment can promote the proliferation of gastric cancer cells, and hypoxic-induced autophagy is the main mechanism of protection against hypoxia in gastric cancer cells. Isorhamnetin (ISO) is a chemical substance derived from plants, mainly from the sea buckthorn. Previous studies have shown that ISO has antitumor effects, but the effects of ISO against gastric cancer in a hypoxic environment are still unknown. In this study, we investigated the effects of ISO against gastric cancer in a hypoxic environment and the mechanisms underlying ISO-induced gastric cancer cell death. The results show that ISO targeted PI3K and blocked the PI3K-AKT-mTOR signaling pathway, significantly inhibiting gastric cancer cell autophagy in a hypoxic environment, inhibiting cell proliferation, decreasing mitochondrial membrane potential, and promoting mitochondria-mediated apoptosis. ISO, a functional food component, is a promising candidate for the treatment of gastric cancer.