文献类型：期刊文献

中文题名：当归挥发油对大鼠局灶性脑缺血再灌注损伤的保护作用

英文题名：Protection of volatile oil from Angelica sinensis on focal cerebral ischemia-reperfusion in rats

作者：罗慧英[1];杨林[1];杨焕[1];刘渊[1]

第一作者：罗慧英

机构：[1]甘肃中医学院药理教研室,甘肃省中药药理与毒理重点实验室

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

年份：2012

卷号：17

期号：4

起止页码：387

中文期刊名：中国临床药理学与治疗学

外文期刊名：Chinese Journal of Clinical Pharmacology and Therapeutics

收录：CSTPCD;;CSCD:【CSCD2011_2012】；

基金：兰州市科技局资助科研项目(2010-1-213)

语种：中文

中文关键词：当归挥发油;脑缺血再灌注;NO;NOS;SOD;GSH-Px

外文关键词：Volatile oil from Angelica sinensis; Cerebral ischemia-reperfusion injury; NO; NOS; SOD; GSH-Px

摘要：目的:探讨当归挥发油对大鼠局灶性脑缺血再灌注损伤的保护作用。方法:采用改良线栓法阻断大鼠大脑中动脉建立脑缺血模型,到达再灌注时限后进行神经功能缺损评分;检测脑梗死体积比、脑含水量及脑血管通透性;血清NO、NOS含量;以及SOD和GSH-Px活性。结果:当归挥发油可有效改善脑缺血再灌注损伤大鼠的神经功能缺损;降低脑梗死体积比、脑血管通透性和脑含水量;降低血清NO、NOS含量;增强SOD和GSH-Px活性。结论:当归挥发油对脑缺血再灌注损伤有显著保护作用,其机制可能与提高脑组织抗氧化能力有关。
AIM： To discuss the protection of volatile oil from Angelica sinensis on focal cerebral ischemia-reperfusion in rats.METHODS： Focal cerebral ischemia-reperfusion injury model was made with suture-occluded method.The neurological deficits of rats were observed after occluding middle cerebral artery for 45 min and reperfusion for 2 hours.The volume of cerebral infarction were measured;the levels of NOS and NO,and the activities of SOD and GSH-Px in serum were detected.RESULTS：Volatile oil from Angelica sinensis could effectively ameliorate the changes induced by cerebral ischemia-reperfusion,including： meliorate the neurological deficits;decrease the levels of NOS and NO and the volume of cerebral infarction;increase the activities of SOD and GSH-Px.CONCLUSION： Volatile oil from Angelica sinensis shows the protection against ischemia-reperfusion injury,and the effect may related to increase antioxidation of the brain tissue.