文献类型：期刊文献

英文题名：EBV-miR-BART14-3p Targets LACTB to Enhance Gastric Cancer Cell Proliferation and Migration

作者：Huang, Xiaomin[1];Zhao, Xuhui[1,3];Qi, Yujiao[3];Lan, Tian[1];Wang, Ruiling[1];Liang, Shuang[1];Ma, Yuxiu[1];Di, Cuixia[2];Li, Hongling[3]

第一作者：Huang, Xiaomin

通信作者：Li, HL[1]

机构：[1]Gansu Univ Chinese Med, Lanzhou, Peoples R China;[2]Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou, Peoples R China;[3]Gansu Prov Hosp, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Hosp, Lanzhou, Peoples R China.

年份：2025

外文期刊名：BIOCHEMICAL GENETICS

收录：;Scopus(收录号：2-s2.0-85217704107);WOS:【SCI-EXPANDED(收录号:WOS:001412772900001)】；

基金：This study was supported by the Natural Science Foundation of China (No.82460561), Natural Science Foundation of Gansu Province(24JRRA586), National Health Commission's Key Laboratory Doctoral Fund Project (NHCDP2022005), Joint Research Fund Project of Gansu Provincial Science and Technology Department (23JRRA1545)

语种：英文

外文关键词：EBV-miR-BART14-3p; Gastric cancer; LACTB; EMT

摘要：Epstein-Barr virus (EBV), the first human virus identified with oncogenic properties, encodes a class of microRNAs known as miR-BART (BamHI-A rightward transcript microRNAs). This study investigates the pivotal role of EBV-miR-BART14-3p in the progression of gastric cancer, particularly focusing on its effects on epithelial-mesenchymal transition (EMT), cell proliferation, and migration. EBV-associated gastric cancer (EBVaGC) is distinguished by unique genomic and epigenomic characteristics, with EBV miRNAs significantly influencing tumor biology by regulating gene expression. Our research demonstrates that EBV-miR-BART14-3p facilitates gastric cancer cell migration and invasion by targeting the tumor suppressor gene LACTB, which in turn activates the Phosphoinositide 3-kinase (PI3K)/AKT signaling pathway, a critical driver of EMT. The suppression of LACTB in EBVaGC highlights its crucial role in inhibiting tumor progression. These findings position EBV-miR-BART14-3p as a key player in gastric cancer development and underscore its potential as both a prognostic biomarker and a therapeutic target for EBVaGC.