文献类型：期刊文献

英文题名：Harnessing extracellular vesicles to tame inflammation: a new strategy for atherosclerosis therapy

作者：Li, Jiawei[1];Wen, Tianliang[2];Li, Xiaoran[2];Cheng, Ruoyao[2];Shen, Junyi[2];Wang, Xin[3];Guo, Zhaoqi[2];Teng, Zhengjie[4];Yi, Lin[1,5];Zhang, Fan[6]

第一作者：李佳蔚

通信作者：Yi, L[1];Yi, L[2];Zhang, F[3]

机构：[1]Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Sch Clin Med 1, Lanzhou, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Affiliated Hosp, Dept Anesthesiol & Surg, Lanzhou, Gansu, Peoples R China;[4]Gansu Univ Chinese Med, Affiliated Hosp, Dept Cardiovasc Med, Lanzhou, Gansu, Peoples R China;[5]Gansu Univ Tradit Chinese Med, Chron Dis Lab, Lanzhou, Gansu, Peoples R China;[6]Gansu Univ Chinese Med, Affiliated Hosp, Geriatr Dept, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou, Gansu, Peoples R China;[2]corresponding author), Gansu Univ Tradit Chinese Med, Chron Dis Lab, Lanzhou, Gansu, Peoples R China;[3]corresponding author), Gansu Univ Chinese Med, Affiliated Hosp, Geriatr Dept, Lanzhou, Gansu, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2025

卷号：16

外文期刊名：FRONTIERS IN IMMUNOLOGY

收录：;Scopus(收录号：2-s2.0-105009591736);WOS:【SCI-EXPANDED(收录号:WOS:001520492000001)】；

基金：The author(s) declare that financial support was received for the research and/or publication of this article. This work was supported by grants from 2025 "Innovation and Entrepreneurship Fund" project for graduate students of Gansu University of Traditional Chinese Medicine, NO. 2025CXCY-012; General Project of the Science and Technology Bureau of Chengguan District, Lanzhou City, NO.2023JSCX0046; Scientific Research Plan Project of Lanzhou Science and Technology Bureau, NO.2020-ZD-63; Natural Science Foundation of Gansu Provincial Department of Science and Technology (Internal Hospital) 2024, NO.24JRRA1035.

语种：英文

外文关键词：atherosclerosis; extracellular vesicles; exosomes; microvesicles; intercellular communication; biomarkers; nanotherapy

摘要：Atherosclerosis (AS) is a chronic inflammatory disease driven by immune dysregulation and vascular inflammation. Extracellular vesicles (EVs) play pivotal roles in intercellular communication, modulating immune responses and inflammatory cascades during AS progression. EVs derived from endothelial cells, macrophages, vascular smooth muscle cells, and platelets transport bioactive molecules (e.g., miRNAs, cytokines) that regulate endothelial dysfunction, macrophage polarization, and plaque instability. Pro-inflammatory EVs exacerbate oxidative stress, foam cell formation, and neutrophil extracellular trap (NET) release, while anti-inflammatory EVs from mesenchymal stem cells or engineered sources attenuate disease by promoting M2 macrophage polarization and suppressing NF-kappa B signaling. This review highlights the dual roles of EVs in AS immunopathology and their therapeutic potential as biomarkers or nanocarriers for targeted anti-inflammatory interventions. Understanding EV-mediated immune crosstalk may unveil novel strategies for atherosclerosis management.