文献类型：期刊文献

中文题名：lncRNA对骨质疏松骨代谢相关信号通路影响的研究进展

英文题名：Advances on the effects of lncRNA on bone metabolism related signaling pathways in osteoporosis

作者：马智勇[1];郭成龙[1]

第一作者：马智勇

机构：[1]甘肃中医药大学附属医院,甘肃兰州730020

第一机构：甘肃中医药大学第二附属医院

年份：2018

卷号：24

期号：4

起止页码：547

中文期刊名：中国骨质疏松杂志

外文期刊名：Chinese Journal of Osteoporosis

收录：CSTPCD;;北大核心:【北大核心2017】；CSCD:【CSCD2017_2018】；

基金：甘肃省中医药管理局2017立项课题(GZK-2017-18);甘肃省重点中医药现代制药工程研究院自立项目(YWW-2015049)

语种：中文

中文关键词：长链非编码RNA;骨质疏松;骨代谢;信号通路

外文关键词：ln cRNA ; Osteoporosis; Bone metabolism; Signaling pathway

摘要：长链非编码RNA(long non-coding RNA,lncRNA)参与了多种生物学过程,在基因表达如转录调控、表观遗传修饰及蛋白翻译后修饰等机制中发挥重要作用,若它们缺乏则会导致蛋白质编码能力的缺失,失调的lncRNA与骨质疏松密切相关。作为骨质疏松(osteoporosis,OP)骨代谢过程中的生物标志物,lncRNA调控骨代谢相关信号通路的作用机制复杂,随着表观遗传学的发展,lncRNA将为OP诊断、治疗及判断预后提供新的靶向目标。本文将从lncRNA与成骨细胞分化相关信号通路、与破骨细胞分化相关信号通路、与钙相关信号通路三个方面对近年来lncRNA与骨质疏松症骨代谢相关信号通路的研究进行综述。
lncRNA（ long non-coding RNAs） is involved in a variety of biological processes and plays an important role in gene expression,such as transcriptional regulation,epigenetic modification and post-translational modification of proteins,which leads to the loss of protein-coding ability. The disorders of lncRNA are closely related to osteoporosis. lncRNA is a biomarker in the metabolic process of osteoporosis and the mechanism of lncRNA regulation of bone metabolism related signaling pathway is complex. With the development of epigenetics,lncRNA will provide a new target for the diagnosis,treatment and prognosis of osteoporosis. In this paper,we summarized the influence of lncRNA on bone metabolism from three aspects： the relationship between lncRNA and osteoblast differentiation-related signal pathway, the relationship between lncRNA and osteoclasts differentiation-related signal pathway,and the relationship between lncRNA and calcium-related signal pathway.