文献类型：期刊文献

英文题名：EPAS1 and VEGFA Polymorphisms Modulate COPD Susceptibility in a High-Altitude Population: A Case-Control Study

作者：Lin, Lin[1];Zhang, Yi[1];Fu, Xiang[1];Zhang, Yangjie[1];Wang, Yunchao[2];Yang, Zhen[1];Ma, Xiaoming[3];Wang, Xinhua[1]

第一作者：林丽;林玲

通信作者：Wang, XH[1];Ma, XM[2]

机构：[1]Gansu Univ Chinese Med, Inst Publ Hlth, Lanzhou, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Inst Basic Med, Lanzhou, Gansu, Peoples R China;[3]Lanzhou Pulm Hosp, Dept Med, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Inst Publ Hlth, Lanzhou, Gansu, Peoples R China;[2]corresponding author), Lanzhou Pulm Hosp, Dept Med, Lanzhou, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2026

卷号：21

外文期刊名：INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

收录：;Scopus(收录号：2-s2.0-105039815472);WOS:【SCI-EXPANDED(收录号:WOS:001779676700001)】；

基金：This study was supported by the following grants: Major Project of the Gansu Provincial Joint Research Fund: 23JRRA1520 (Xinhua Wang); Lanzhou City Major Projects: HXLH-JBGS03 (Xinhua Wang); Project Approval by the Northwest Collaborative Innovation Center for Traditional Chinese Medicine Prevention and Control: ZYXT-25-09 (Zhen Yang).

语种：英文

外文关键词：chronic obstructive pulmonary disease; EPAS1; VEGFA; gene polymorphism; high altitude

摘要：Background: The onset and progression of Chronic Obstructive Pulmonary Disease (COPD) are influenced by both environmental and genetic factors. Persistent hypoxia at high altitudes is a major environmental stressor. Under hypoxic conditions, EPAS1 is stably expressed and activates its downstream target gene VEGFA; however, the underlying mechanisms remain unclear. Methods: We conducted a case-control study in Gansu Province: to evaluate the association between EPAS1 gene polymorphisms (rs4953354, rs6743991, rs7589861, rs13419896) and susceptibility to COPD in high-altitude populations, we enrolled 517 patients and 580 controls (no significant differences in ethnic distribution, no stratification was performed); To evaluate the association of VEGFA gene polymorphisms (rs10434, rs2010963, rs3025020, rs833070) in Tibetan and Han populations, we enrolled 397 patients (148 Tibetans, 249 Han) and 807 controls (251 Tibetans, 556 Han). Results: For EPAS1, rs4953354 A>G was associated with a decreased risk of COPD (AG vs. AA: OR = 0.680, 95% CI = 0.523-0.885; AG+GG vs. AA: OR = 0.708, 95% CI = 0.551-0.910). For VEGFA, in Han population, rs2010963 C>G (CG vs. CC: OR = 1.619, 95% CI = 1.070-2.449; GG vs. CC: OR = 1.751, 95% CI = 1.119-2.740; CG+GG vs. CC: OR = 1.670, 95% CI = 1.133-2.462) and rs3025020 C>T (TT vs. CC: OR = 2.290, 95% CI = 1.321-3.971; TT vs. CT+CC: OR = 2.151, 95% CI = 1.276-3.626) were associated with an increased risk of COPD. Conversely, in the Tibetan population, rs3025020 C>T was associated with a decreased risk of COPD (CT vs. CC: OR = 0.530, 95% CI = 0.329-0.853; CT+TT vs. CC: OR = 0.571, 95% CI = 0.365-0.893). No significant associations were observed for other loci. Conclusion: This study reveals that EPAS1 and VEGFA gene polymorphisms are associated with susceptibility to COPD in populations residing at high altitudes.