文献类型：期刊文献

中文题名：中药复方干预慢性阻塞性肺疾病氧化应激的研究进展

英文题名：Intervention of Chinese Herbal Medicine Formulas on Oxidative Stress ofChronic Obstructive Pulmonary Disease: A Review

作者：郝彬彬[1];把得婷[1];李娟[2];李金田[3]

第一作者：郝彬彬

机构：[1]甘肃中医药大学,甘肃省中药新产品创制工程实验室,甘肃省中医方药挖掘与创新转化重点实验室,兰州730000;[2]甘肃中医药大学基础医学院,兰州730101;[3]甘肃中医药大学中医临床学院,兰州730101

第一机构：甘肃中医药大学科研实验中心（甘肃省中医药标准化技术委员会秘书处）

年份：2024

卷号：30

期号：3

起止页码：218

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：CSTPCD;;Scopus;北大核心:【北大核心2023】；CSCD:【CSCD2023_2024】；

基金：国家自然科学基金项目(81460709,82160872);甘肃省教育厅“双一流”科研重点项目(GSSYLXM-05);甘肃省中医药研究中心开放课题项目(zyzx-2020-zx3)。

语种：中文

中文关键词：中药复方;慢性阻塞性肺疾病;氧化应激;基础研究;临床研究

外文关键词：Chinese herbal medicine formulas;chronic obstructive pulmonary disease;oxidative stress;basic research;clinical research

摘要：慢性阻塞性肺疾病(COPD)是临床中常见的疾病,与明显暴露于有毒颗粒或气体相关,已成为全球死亡和致残的主要原因。COPD发病机制复杂,其中涉及的氧化应激在疾病的病理进程中发挥着至关重要的作用。COPD患者肺部通常存在高水平的氧化应激,长期将影响全身,出现多种并发症,加速病情发展。一方面,氧化应激可直接损伤气道和肺组织;另一方面,还驱动其他病理机制共同促进疾病发展,如参与炎症反应、参与蛋白酶/抗蛋白酶失衡、促进黏液分泌、加速细胞衰老、引起自身免疫及参与遗传调控途径等。目前西医治疗多在常规药物治疗的基础上,采取抗氧化剂靶向氧化应激,但在疗效及安全性方面还面临一些挑战。中医药防治COPD历史悠久,尤其是中药复方在干预COPD的氧化应激方面体现出较大潜力。无论是中医经典名方加减化裁还是现代医家进行新的组方,研究结果均体现出中医药治疗的多靶点、多途径优势,在疗效及安全性方面也日渐得到验证。现梳理近几年文献,从中药复方干预COPD氧化应激的基础研究及临床研究入手,以期为中医药防治COPD氧化应激的相关研究提供进一步思路。
Chronic obstructive pulmonary disease(COPD)is a common disease in clinical practice.It is associated with obvious exposure to toxic particles or gases and has become the leading cause of death and disability worldwide.The pathogenesis of COPD is complex,and the oxidative stress involved in COPD plays a crucial role in the pathological process of the disease.Patients with COPD usually have high levels of oxidative stress in the lungs, which will affect the whole body for a long time, causing a variety of complications andaccelerating the development of the disease. On the one hand, oxidative stress can directly damage the airwayand lung tissue. On the other hand, it also drives other pathological mechanisms to jointly promote thedevelopment of disease, such as participating in inflammatory reactions and protease/anti-protease imbalance,promoting mucus secretion, accelerating cellular senescence, causing autoimmunity, and involving in geneticregulatory pathways. At present, western medicine treatment is mostly based on conventional drug treatment,and antioxidant-targeted oxidative stress is adopted, but there are still some challenges in efficacy and safety.Traditional Chinese medicine has a long history of preventing and treating COPD. In particular, Chinese herbalmedicine formulas have great potential to interfere with the oxidative stress of COPD. Whether it is the modifiedclassical traditional Chinese medicine or the new formulation developed by modern doctors, the research resultsreflect the multi-target and multi-channel advantages of traditional Chinese medicine treatment, and theirefficacy and safety are gradually verified. This paper reviewed the literature in recent years, starting with thebasic and clinical research on the intervention of traditional Chinese herbal medicine formulas on oxidative stressof COPD, so as to provide further ideas for related research on the prevention and treatment of oxidative stress ofCOPD by traditional Chinese medicine.