文献类型：期刊文献

中文题名：杜仲提取物及有效成分防治肌萎缩性侧索硬化症的可行性分析

英文题名：Study on pharmacological effects of Eucommia ulmoides extract and its active ingredients in preventing and treating amyotrophic lateral sclerosis

作者：赵继荣[1];张立存[1];赵宁[2];陈祁青[2];王兴盛[2];朱宝[2];徐兵[1];杨涛[1];李玮农[1]

第一作者：赵继荣

机构：[1]甘肃中医药大学,甘肃兰州700030;[2]甘肃省中医院,甘肃兰州700050

第一机构：甘肃中医药大学

年份：2021

卷号：44

期号：3

起止页码：667

中文期刊名：药物评价研究

外文期刊名：Drug Evaluation Research

收录：CSTPCD

基金：兰州市创新人才项目(2018-RC-99);国家自然科学基金资助项目(81760877);甘肃省中医药管理局重点课题(GZKZ-2020-3);甘肃省中医药项目(GZK-2019-2)。

语种：中文

中文关键词：杜仲;有效成分;药理作用;肌萎缩性侧索硬化症

外文关键词：Eucommia ulmoides;active ingredient;pharmacological effects;amyotrophic lateral sclerosis

摘要：肌萎缩性侧索硬化症(Amyotrophic lateral sclerosis,ALS)是运动神经元病变相关疾患中最常见的类型之一,致残致死率高,严重影响患者生活质量,给家庭带来了沉重的负担。其主要病理机制为多种因素导致运动神经元损伤变性,保护神经元乃行之有效的治疗方法。补益类中药杜仲来源于杜仲Eucommia ulmoides的干燥树皮,现代药理研究证实其有效成分具有神经保护、抗氧化应激等作用而被广泛运用于临床神经退行性疾患的防治。以当前对ALS发病机制的主流认识为出发点,探讨杜仲提取物及有效成分防治ALS的可行性,以期为杜仲防治ALS方面的开发应用有所裨益。
Amyotrophic lateral sclerosis(ALS) is one of the most common types of motor neuron disease-related diseases. It has a high disability and fatality rate, which seriously affects the quality of life of patients and brings a heavy burden to families. The main pathological mechanism is that a variety of factors cause motor neuron damage and degeneration. Protecting neurons is an effective treatment. Eucommia ulmoides is a traditional Chinese medicinal material for tonics in my country. Modern pharmacology has confirmed that its active ingredients have neuroprotective and anti-oxidative stress effects and are widely used in the prevention and treatment of clinical neurodegenerative diseases. Based on the current mainstream understanding of the pathogenesis of ALS, this article discusses the feasibility of Eucommia ulmoides and its active ingredients in the prevention and treatment of ALS, hoping to benefit the development and application of Eucommia ulmoides in the prevention and treatment of ALS in the future.