文献类型：期刊文献

中文题名：中医药防治少弱精子症的研究现状

英文题名：Research status of Chinese medicine in the prevention and treatment of oligozoospermia

作者：冀小卫[1];杨佳树[1];剡锐[2];刘黎明[1];邢喜平[3]

第一作者：冀小卫

机构：[1]甘肃中医药大学中西医结合学院,甘肃兰州730000;[2]兰州大学第一医院男科,甘肃兰州730000;[3]甘肃中医药大学附属医院男科,甘肃兰州730000

第一机构：甘肃中医药大学中西医结合学院

年份：2024

卷号：40

期号：21

起止页码：3196

中文期刊名：中国临床药理学杂志

外文期刊名：The Chinese Journal of Clinical Pharmacology

收录：CSTPCD;;北大核心:【北大核心2023】；CSCD:【CSCD2023_2024】；

基金：甘肃省中医药科研课题(GZKP-2023-15);第一批陇原青年英才培养项目(甘人社通[2021]404号);甘肃省卫生健康行业骨干人才基金资助项目(甘卫人函[2023]398号);兰州市科技发展指导性计划项目(2023-ZD-102)。

语种：中文

中文关键词：中医药;少弱精子症;研究现状

外文关键词：Chinese medicine;oligozoospermia;research status

摘要：Kelch样环氧氯丙烷相关蛋白1/转录因子NF-E2相关因子2/血红素加氧酶1(Keap1/Nrf2/HO-1)、磷脂酰肌醇-3激酶/蛋白激酶B/哺乳动物西罗莫司靶蛋白(PI3K/Akt/mTOR)、干细胞生长因子/酪氨酸酶受体(SCF/c-kit)、肝激酶B1/腺苷酸活化蛋白激酶(LKB1/AMPK)等信号通路在少弱精子症(OAS)的发生发展中具有不可替代的作用,以其相关信号为靶点的研究是目前防治OAS的热点。本文以上述信号通路为突破口,系统总结中药提取物、中成药、中药复方及针灸等中医外治法干预相关信号通路治疗OAS的作用机制,以期为临床实践提供理论依据和指导。
Objective Kelch-like epichlorohydrin-associated protein 1/transcription factor NF-E2-associated factor 2/hemoglobin oxygenase 1(Keap1/Nrf2/HO-1),phosphatidylinositol-3 kinase/protein kinase B/rapamycin protein(PI3K/Akt/mTOR),stem cell growth factor/tyrosinase receptor(SCF/c-kit),liver kinase B1/adenylate-activated protein kinase(LKB1/AMPK)and other signaling pathways have irreplaceable roles in the development of oligospermia(OAS),and the study of targeting their related signals is a hotspot for the prevention and treatment of OAS.Therefore,taking many signaling pathways as breakthroughs.The review systematically summarized the mechanism of action of Chinese medicine extracts,proprietary Chinese medicines,Chinese medicine prescriptions and external Chinese medicine treatments such as acupuncture and moxibustion that intervene in the relevant signaling pathways for the treatment of OAS,with a view to providing theoretical basis and guidance for clinical practice.