文献类型：期刊文献

中文题名：miR对骨质疏松骨代谢信号通路影响的研究进展

英文题名：The research progress of the effect of miR on bone metabolism signal pathway in osteoporosis

作者：宋敏[1];巩彦龙[1];刘涛[1];董万涛[2];李清林[1];孙定平[1];周灵通[1]

第一作者：宋敏

机构：[1]甘肃中医药大学;[2]甘肃中医药大学附属医院

第一机构：甘肃中医药大学

年份：2016

卷号：22

期号：9

起止页码：1195

中文期刊名：中国骨质疏松杂志

外文期刊名：Chinese Journal of Osteoporosis

收录：CSTPCD;;北大核心:【北大核心2014】；CSCD:【CSCD2015_2016】；

基金：国家自然科学基金(81360554);甘肃省重点中医药现代制药工程研究院自立项目(YWW-2015049);甘肃省中医药防治慢性疾病重点实验室(BH2010-428)

语种：中文

中文关键词：miR;信号通路;骨代谢;骨质疏松

外文关键词：miR; Signal pathway; Bone metabolism; Osteoporosis

摘要：miR在骨骼发育、代谢过程中具有重要的生物学功能,能够调控骨细胞生长、分化和功能表达。正常机体中,骨代谢相关信号通路对维持骨骼正常生物学功能意义重大,miR通过与骨代谢相关的多种信号通路调节成骨细胞/破骨细胞代谢,达到有利于机体的平衡状态,如果miR表达失调这种稳态就会失衡,相关信号通路被激活,导致相应的骨代谢疾病,如骨质疏松症。信号通路作为调控骨代谢的重要途径,不同信号通路机制之间存在一定的联系,但是大多数信号通路的确切机制还不明了,各通路之间的相互联系研究较少,随着表观遗传学的发展,miR通过相关信号通路精密调控骨代谢的机制被逐步阐明。miR与多种骨质疏松多种信号通路存在密切的关系,成为潜在的检测标志物和治疗靶向点。研究miR参与调控骨质疏松骨代谢相关信号通路的机制,在骨质疏松的预防、诊治及预后意义重大。本文将从三个方面对近年来miR对骨质疏松症骨代谢相关信号通路的研究作以概述。
miR plays an important biological role in skeletal development and metabolism.It regulates bone cell growth,differentiation,and functional expression.In the normal body,the signal pathway of bone metabolism is of great significance to the maintenance of normal biological function of the bone.miR regulates osteoblast/osteoblast metabolism through various signal pathways related to bone metabolism,which is beneficial to the balance of the body.If the of miR expression is imbalance,the related signal pathway is activated,leading to the corresponding bone metabolic diseases such as osteoporosis.Signal pathway is a important way of regulating bone metabolism.There are certain connections between different signal pathways.However,mechanism related to signal pathway is unclear and the related research is few.The mechanism of miR related signal pathways of precise control of bone metabolism has been gradually elucidated with the development of epigenetics.miR is closely related to a variety of osteoporosis signal pathways.It has become a potential detection markers and a therapeutic target.It is of great significance of the study the mechanism of miR-involved regulation of bone metabolism and related signaling pathways,and the prevention,diagnosis,and treatment of osteoporosis.This paper summarizes the research of miR in bone metabolism related signal pathway in osteoporosis in recent years from three aspects.