文献类型：期刊文献

中文题名：妇科再造胶囊对环磷酰胺所致免疫功能低下小鼠的保护作用

英文题名：Protective Effect of Fuke Zaizao Capsules on Immunity Deficiency Induced by Cyclophosphamide in Mice

作者：朱丽娟[1];罗建云[2];康文斌[1];宋潇[1]

第一作者：朱丽娟

机构：[1]甘肃中医学院药理学教研室,兰州730000;[2]西安市卫生局

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

年份：2013

卷号：16

期号：7

起止页码：961

中文期刊名：中国药师

外文期刊名：China Pharmacist

收录：CSTPCD

语种：中文

中文关键词：妇科再造胶囊;环磷酰胺;免疫低下

外文关键词：Fuke Zaizao capsules; Cyclophosphamide; Immune deficiency

摘要：目的:探讨妇科再造胶囊对环磷酰胺所致免疫低下小鼠免疫功能的影响。方法:用环磷酰胺(100 mg·kg^(-1),ip)制备小鼠免疫低下模型,灌胃给予不同剂量的妇科再造胶囊(20,40,80 g·L^(-1)),观察小鼠外周血白细胞计数、免疫器官指数、单核吞噬细胞吞噬指数以及血清溶血素水平结果:与模型组比较,妇科再造胶囊能够增加免疫功能低下小鼠外周血白细胞数量(P<0.01)及免疫器官指数(P<0.01),并且可以增强单核吞噬细胞的吞噬能力(P<0.05),提高血清溶血素水平(P<0.05)。结论:妇科再造胶囊能够增强环磷酰胺所致免疫功能低下小鼠特异性和非特异性免疫功能,并呈一定的剂量依赖性。
To investigate the effect of Fuke Zaizao capsules（FKZZ ） on immunity deficiency induced by cyclophosphamide in mice.Method：The experimental mouse model of immunity deficiency was produced by intraperitoneal injection（ip） of cyclophosphamide（CTX） with a dose of 100 mg·kg^（-1）.The mice were randomly divided into the normal control group,immunity deficiency model group,FKZZ group（treated with FKZZ with the dose of 20,40 and 80 g·L^（-1）,respectively）.The number of WBC in peripheral blood,the weight of immune organs,the phagocytosis activity of macrophage and the content of serum hemolysin were measured. Result：Compared with the model group,FKZZ could increase the amount of WBC（P 0.01 ）,the weight of immune organs（P 0.01 ）,the phagocytosis activity of macrophage（P0.05）and the content of serum hemolysin（P 0.05）.Conclusion：FKZZ can enhance nonspecific and specific immunity function,and improve the condition of immunity deficiency induced by cyclophosphamide in mice with dose - dependent manner.