文献类型：期刊文献

英文题名：Hydrogen Sulfide-Regulated NF-κB Signaling via Persulfidation: A Review

作者：Xu, Liang[1,2];Liang, Keke[1,2];Wang, Renjie[2,3];Ta, Yanling[1,2];Yang, Yongrun[1,2];Wang, Jiaxing[1,2];Zhang, Xianxie[1,2];Wang, Yuguang[2,3];Xiao, Chengrong[2];Wang, Yihao[2];Li, Maoxing[1,2,3]

第一作者：许丽;Xu, Liang

通信作者：Li, MX[1];Wang, YH[2];Li, MX[2]

机构：[1]Gansu Univ Chinese Med, Coll Pharm, Lanzhou 730000, Peoples R China;[2]Acad Mil Med Sci, Beijing 100850, Peoples R China;[3]Tianjin Univ Tradit Chinese Med, Coll Tradit Chinese Med, Tianjin 300193, Peoples R China

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Coll Pharm, Lanzhou 730000, Peoples R China;[2]corresponding author), Acad Mil Med Sci, Beijing 100850, Peoples R China.|[1073501e14fb35863569f]甘肃中医药大学药学院（西北中藏药协同创新中心办公室）;[10735]甘肃中医药大学;

年份：2026

卷号：16

期号：8

外文期刊名：BIOMOLECULES

收录：;Scopus(收录号：2-s2.0-105048481684);WOS:【SCI-EXPANDED(收录号:WOS:001859259700001)】；

基金：This study was supported by the Innovation Star Project for Outstanding Graduate Students of the Gansu Provincial Department of Education (grant 2026CXZX-922), the Excellent Doctoral Student Program of Gansu Province (grant 25JRRA258), the Traditional Chinese Medicine Service Capacity Building Project (grant 2023ZY010), and the Key Research and Development and Transformation Key Special Project of the Tibet Autonomous Region Science and Technology Plan for 2026 (grant XZ202601ZY0218).

语种：英文

外文关键词：hydrogen sulfide (HS); persulfidation (or persulfidation modification); nuclear factor kappa B (NF-kappa B) signaling pathway; inflammation; oxidative stress

摘要：Hydrogen sulfide (H2S) is an important endogenous gaseous signaling molecule that regulates diverse physiological and pathological processes through protein persulfidation. As a central regulator of inflammation and immune responses, NF-kappa B signaling is precisely controlled by post-translational modifications, and its dysregulation contributes to various inflammatory diseases. Recent studies reveal that H2S-mediated persulfidation is a key mechanism for fine-tuning NF-kappa B activity by targeting critical components, including p65, IKK beta, I kappa B alpha, and upstream regulators. Through site-specific S-sulfhydration, H2S modulates IKK activation, I kappa B alpha degradation, and p65 nuclear translocation, thereby limiting excessive NF-kappa B activation and inflammatory cytokine production. This review provides an integrated view of how endogenous H2S production and persulfidation-dependent signaling regulate inflammatory responses. Rather than simply summarizing individual pathways, we focus on the molecular mechanisms underlying H2S-mediated regulation of NF-kappa B-associated networks, including TLR4/NF-kappa B, PI3K/Akt/NF-kappa B, and MAPK/NF-kappa B pathways, and highlight its roles in oxidative stress, apoptosis, pyroptosis, and tissue repair. We further discuss current challenges in identifying persulfidation sites, understanding endogenous H2S regulation, and improving detection technologies. By proposing H2S as a precision modulator of inflammatory signaling, this review provides new insights into H2S biology and highlights future opportunities for developing targeted H2S-based therapeutic strategies.