文献类型：期刊文献

英文题名：Targeting lactate metabolism in the tumor microenvironment: Immunomodulation and prospects for antitumor therapy

作者：Yan, Jingnan[1];Qi, Yafeng[1];Liu, Yeyuan[1];Jiang, Xiaodan[1];Li, Yangyang[2,4];Song, Zhongyang[3];Zhang, Liying[2,4];Zhang, Zhiming[1,5]

第一作者：Yan, Jingnan

通信作者：Zhang, ZM[1];Zhang, LY[2];Zhang, LY[3];Zhang, ZM[4]

机构：[1]Gansu Univ Tradit Chinese Med, Clin Sch Tradit Chinese Med, Lanzhou 730000, Peoples R China;[2]Gansu Univ Chinese Med, Prov Key Lab Mol Med & Prevent Res Major Dis, Lanzhou 730000, Peoples R China;[3]Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou 730000, Peoples R China;[4]Gansu Univ Tradit Chinese Med, Key Lab Dunhuang Med & Translat Educ Minist Educ, Lanzhou 730000, Peoples R China;[5]Gansu Prov Hosp Tradit Chinese Med, Dept Oncol, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Clin Sch Tradit Chinese Med, Lanzhou 730000, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Prov Key Lab Mol Med & Prevent Res Major Dis, Lanzhou 730000, Peoples R China;[3]corresponding author), Gansu Univ Tradit Chinese Med, Key Lab Dunhuang Med & Translat Educ Minist Educ, Lanzhou 730000, Peoples R China;[4]corresponding author), Gansu Prov Hosp Tradit Chinese Med, Dept Oncol, Lanzhou 730000, Peoples R China.|[10735]甘肃中医药大学;

年份：2025

卷号：164

外文期刊名：INTERNATIONAL IMMUNOPHARMACOLOGY

收录：;Scopus(收录号：2-s2.0-105013848116);WOS:【SCI-EXPANDED(收录号:WOS:001571592400003)】；

基金：This research was supported by Gansu Provincial Science and Technology Major Special Fund Project (22ZD1FA001) ; Gansu Province Joint Research Fund Major Project (23JRRA1530) ; Lanzhou City Science and Technology Plan Project (2025-2-3) ; Silver Age Expert Studio in Gansu Province (No. Provincial Party Committee Talent Group [2025] No. 4) ; National Natural Science Foundation of China funded project (82460925, 81160882) ; Construction Project of the Advanced Talent Studio for Traditional Chinese Medicine (Zhang Zhiming, Ganca Society [2021] No. 125) ; Gansu Province Natural Science Foundation (24YFFA067) .

语种：英文

外文关键词：Lactate metabolism; Tumor microenvironment; Immune cells; Targeted therapy; Traditional Chinese medicine; Traditional Chinese medicine

摘要：Disturbed lactate metabolism in the tumor microenvironment (TME) is a key factor driving malignant tumor progression. Recent studies have revealed that lactate is not only a metabolic by-product of glycolysis, but also an important signaling molecule that regulates tumor cell and immune cell functions. Lactate remodels TME through metabolic-signaling-immune interactions, inhibits the activity of effector immune cells, and promotes the expansion of immunosuppressive cells, thus weakening the anti-tumor immune response. This review systematically describes the regulatory network of lactate metabolism in the TME, focuses on analyzing the role of lactate on different immune cells, and explores innovative therapeutic strategies and clinical translational pathways that target lactate production/transport, neutralize the acidic environment, and multi-target remodeling of lactate homeostasis by traditional Chinese medicine (TCM), which will provide the basis for the formulation of precise antitumor treatment protocols based on metabolic remodeling and optimization of novel combinatorial therapies, and ultimately achieve an overall enhancement of the effectiveness of clinical cancer treatment.