文献类型：期刊文献

中文题名：生津利咽含片的急性毒性实验

英文题名：Acute Toxicity Test on Shengjin Liyan Lozenges

作者：虎峻瑞[1];杨胜刚[2];段永强[1];朱立鸣[1];梁玉杰[1];张春燕[1]

第一作者：虎峻瑞

机构：[1]甘肃中医学院;[2]新疆库尔勒市普惠地区中心医院,新疆库尔勒841000

第一机构：甘肃中医药大学

年份：2009

卷号：29

期号：3

起止页码：252

中文期刊名：河南中医

外文期刊名：Henan Traditional Chinese Medicine

收录：CSTPCD

基金：甘肃省教育厅2005年重点资助项目(编号:0505-03)

语种：中文

中文关键词：生津利咽含片;急性毒性实验;小鼠

外文关键词：Shengjin Liyan Lozenges; acute toxicity test; mice

摘要：目的:观察生津利咽含片7 d内连续最大剂量灌胃给药后小鼠的急性毒性反应及死亡情况。方法:给SPF级昆明种小鼠灌服生津利咽含片,未测出LD50,故作最大给药量测试。结果:测得最大给药量为120.0 g/kg,相当于60 kg成人日用量的1 446倍。结论:生津利咽含片灌胃给药后,小鼠无急性毒性反应。
To observe the acute toxicity reaction and the death status of mice administered with the most tolerance dose of Shengjin Liyan. Lozenges consistently for 7 days by gavage. Method： Kunming SPF mice were administered with Shengjin Liyan Lozenges. Since no LD50 was found in mice, they were administered with the most tolerance dose. Result： The most tolerance dose was 120.0g/kg, which was equivalent to 1.446 times of 60kg edult＇s daily dosage. Conclusion： Mice have no acute toxicity reaction after the gastric perfusion of Shengjin Liyan Lozenges.