文献类型：期刊文献

英文题名：An immune-related prognostic signature associated with immune landscape and therapeutic responses in gastric cancer

作者：Sun, Jian-Rong[1];Kong, Chen -Fan[2];Qu, Xiang-Ke[1];Sun, An -Tao[3];Zhao, Kun-Peng[4];Sun, Jin-Hui[5]

第一作者：Sun, Jian-Rong

通信作者：Sun, JR[1]

机构：[1]Beijing Univ Chinese Med, Sch Clin Med, Beijing 100029, Peoples R China;[2]Shanghai Univ Tradit Chinese Med, Sch Clin Med, Shanghai 201203, Peoples R China;[3]Guanganmen Hosp, Dept Hematol, Beijing 100053, Peoples R China;[4]Gansu Univ Chinese Med, Sch Tradit Chinese Med, Lanzhou 730000, Peoples R China;[5]Beijing Univ Chinese Med, Dept Gastroenterol, Affiliated Dongzhimen Hosp, Beijing 100700, Peoples R China

第一机构：Beijing Univ Chinese Med, Sch Clin Med, Beijing 100029, Peoples R China

通信机构：[1]corresponding author), Beijing Univ Chinese Med, Sch Clin Med, Beijing 100029, Peoples R China.

年份：2023

卷号：15

期号：4

外文期刊名：AGING-US

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000941576100003)】；

基金：This study was supported by the National Natural Science Foundation of China (Grant No. 81660772).

语种：英文

外文关键词：gastric cancer; immune-related signature; prognosis; immune infiltration; immunotherapy

摘要：Immune-related genes (IRGs) have attracted attention in recent years as therapeutic targets in various tumors. However, the role of IRGs in gastric cancer (GC) has not been clearly elucidated. This study presents a comprehensive analysis exploring the clinical, molecular, immune, and drug response features characterizing the IRGs in GC. Data were acquired from the TCGA and GEO databases. The Cox regression analyses were performed to develop a prognostic risk signature. The genetic variants, immune infiltration, and drug responses associated with the risk signature were explored using bioinformatics methods. Lastly, the expression of the IRS was verified by qRT-PCR in cell lines. In this manner, an immune-related signature (IRS) was established based on 8 IRGs. According to the IRS, patients were divided into the low-risk group (LRG) and high-risk group (HRG). Compared with the HRG, the LRG was characterized by a better prognosis, high genomic instability, more CD8+ T cell infiltration, greater sensitivity to chemotherapeutic drugs, and greater likelihood of benefiting from the immunotherapy. Moreover, the expression result showed good consistency between the qRT-PCR and TCGA cohort. Our findings provide insights into the specific clinical and immune features underlying the IRS, which may be important for patient treatment.