文献类型：期刊文献

英文题名：Neurotrophins and neural stem cells in posttraumatic brain injury repair

作者：Guo, Wenwen[1,2];Liu, Ke[1,2];Wang, Yinghua[3];Ge, Xu[1];Ma, Yifan[2];Qin, Jing[1];Zhang, Caiqin[1];Zhao, Ya[1,4];Shi, Changhong[1,4]

第一作者：Guo, Wenwen

通信作者：Zhao, Y[1];Shi, CH[1]

机构：[1]Fourth Mil Med Univ, Lab Anim Ctr, Xian, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Lanzhou, Peoples R China;[3]Yanan Univ, Med Coll, Yanan, Peoples R China;[4]Fourth Mil Med Univ, Lab Anim Ctr, Xian 710032, Shaanxi, Peoples R China

第一机构：Fourth Mil Med Univ, Lab Anim Ctr, Xian, Peoples R China

通信机构：[1]corresponding author), Fourth Mil Med Univ, Lab Anim Ctr, Xian 710032, Shaanxi, Peoples R China.

年份：2024

卷号：7

期号：1

起止页码：12

外文期刊名：ANIMAL MODELS AND EXPERIMENTAL MEDICINE

收录：Scopus(收录号：2-s2.0-85178189685);WOS:【ESCI(收录号:WOS:001111429800001)】；

基金：The work was supported by the Shaanxi Province Innovation Capability Support Plan (2022PT-38), Laboratory Animal Foundation Program of Military (no. SYDW [2018]01), and the Military Medical Promotion Plan of the Air Force Medical University (no. 2020SWAQ11).

语种：英文

外文关键词：mutual effect; neural stem cells; neurological function; neurotrophins; traumatic brain injury

摘要：Traumatic brain injury (TBI) is the main cause of disability, mental health disorder, and even death, with its incidence and social costs rising steadily. Although different treatment strategies have been developed and tested to mitigate neurological decline, a definitive cure for these conditions remains elusive. Studies have revealed that various neurotrophins represented by the brain-derived neurotrophic factor are the key regulators of neuroinflammation, apoptosis, blood-brain barrier permeability, neurite regeneration, and memory function. These factors are instrumental in alleviating neuroinflammation and promoting neuroregeneration. In addition, neural stem cells (NSC) contribute to nerve repair through inherent neuroprotective and immunomodulatory properties, the release of neurotrophins, the activation of endogenous NSCs, and intercellular signaling. Notably, innovative research proposals are emerging to combine BDNF and NSCs, enabling them to synergistically complement and promote each other in facilitating injury repair and improving neuron differentiation after TBI. In this review, we summarize the mechanism of neurotrophins in promoting neurogenesis and restoring neural function after TBI, comprehensively explore the potential therapeutic effects of various neurotrophins in basic research on TBI, and investigate their interaction with NSCs. This endeavor aims to provide a valuable insight into the clinical treatment and transformation of neurotrophins in TBI, thereby promoting the progress of TBI therapeutics. Neurotrophins act on the Trk and P75 receptor pathways to improve traumatic brain injury (TBI)-induced inflammation, abnormal neurogenesis, and functional impairments. The interaction between neurotrophins and endogenous neural stem cells (NSCs) plays synergistic role in the TBI repair process. Further transplantation of neurotrophins, combined with NSCs enables targeted delivery of neurotrophins and significantly enhances the reparative capacity at the site of injury.image