文献类型：期刊文献

英文题名：Giant dedifferentiated liposarcoma of the neck with osteosarcoma and chondrosarcoma components: A case report

作者：Zeng, Jiankang[1,2];Gao, Rong[2];Yang, Kai[2];Li, Jiahuan[1,2];Tan, Fei[1,2];Li, Peijie[1,2];Wang, Xin[1,2];Wang, Jin[1,2];Qiao, Yongjie[1];Zhou, Shenghu[1]

第一作者：Zeng, Jiankang

通信作者：Qiao, YJ[1];Zhou, SH[1]

机构：[1]940 Hosp Joint Logist Support Force Chinese People, Dept Joint Surg, 333 South Riverside Rd, Lanzhou 730050, Gansu, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Dept Clin Med Coll 1, Lanzhou 730050, Gansu, Peoples R China

第一机构：940 Hosp Joint Logist Support Force Chinese People, Dept Joint Surg, 333 South Riverside Rd, Lanzhou 730050, Gansu, Peoples R China

通信机构：[1]corresponding author), 940 Hosp Joint Logist Support Force Chinese People, Dept Joint Surg, 333 South Riverside Rd, Lanzhou 730050, Gansu, Peoples R China.

年份：2025

卷号：22

期号：3

外文期刊名：MOLECULAR AND CLINICAL ONCOLOGY

收录：Scopus(收录号：2-s2.0-85217258653);WOS:【ESCI(收录号:WOS:001417232500001)】；

基金：This study was funded by the High-Level Talent Cultivation Project at the 940th Hospital of Joint Logistics Support Force (grant no. 2024-G3-5), the Lanzhou Science and Technology Project (grant nos. 2023-2-11 and 2023-ZD-170) and the Gansu University of Traditional Chinese Medicine Mentorship Project (grant no. 2023YXKY015).

语种：英文

外文关键词：dedifferentiated; liposarcoma; osteosarcoma; chondrosarcoma

摘要：Dedifferentiated liposarcoma (DDLPS) is a subtype of LPS characterized by two distinct levels of differentiation and morphological structures, comprising areas of well-differentiated LPS and dedifferentiated, non-lipogenic, highly malignant components. DDLPS most frequently occurs in the retroperitoneum and the soft tissues of the pelvis and limbs, and is rare in the head and neck region, accounting for only 1% of head and neck sarcomas. The present study describes the case of a 72-year-old male with a 30-year history of left upper limb numbness and heaviness. During physical examination, a tumor measuring similar to 13x22 cm was discovered in the left posterior region of the head and neck. The mass was hard in texture and had limited mobility. A biopsy of the lesion revealed a mesenchymal tumor rich in adipose components with ossification, containing heterologous elements primarily indicative of osteosarcoma, highly suggestive of DDLPS. A radical excision of the tumor was subsequently performed. The surgical specimen exhibits cross-sections with a gray-white to gray-yellow solid consistency, featuring gray-white, semi-transparent areas resembling cartilage. Immunohistochemical staining was positive for murine double minute 2 (MDM2), cyclin-dependent kinase 4 (CDK4), P16, P53, Vimentin and Ki-67, and negative for cytokeratin pan, S-100, CD34 and smooth muscle actin. Fluorescence in situ hybridization results indicated amplification of the MDM2 and CDK4 genes. In the present study, a case of a large DDLPS in the neck with components of osteosarcoma and chondrosarcoma was reported. There was no recurrence during the follow-up period. The pathological characteristics, diagnosis and current treatment methods for DDLPS were also described. Although cases of DDLPS have been reported, the number of cases described at this site remains limited to date, and it is currently not possible to accurately predict the treatment efficacy and prognosis.