文献类型：期刊文献

英文题名：Association between D-dimer levels and clinicopathological characteristics of pancreatic cancer and its role in prognosis: A systematic review and meta-analysis

作者：Wu, Bin[1,2,3];Zhang, Guangming[2,3,6];Zhao, Xiashuang[1,2,3];Wang, Jie[1,2,3];Wang, Da[2,3,4];Zhang, Yipeng[1,2,3];Yu, Miao[2,3,5];Cai, Hui[1,2,3,5,6]

第一作者：吴冰;Wu, Bin

通信作者：Cai, H[1]

机构：[1]Gansu Univ Chinese Med, Gansu Prov Hosp, Clin Med Coll 1, Lanzhou 730000, Peoples R China;[2]Gansu Prov Hosp, Key Lab Mol Diagnost & Precis Med Surg Oncol Gansu, Lanzhou 730000, Peoples R China;[3]Gansu Prov Hosp, Gen Surg Clin Med Ctr, Lanzhou 730000, Peoples R China;[4]Jiangsu Univ, Zhenjiang 212000, Peoples R China;[5]Gansu Prov Hosp, 204 West Donggang RD, Lanzhou 730000, Peoples R China;[6]Lanzhou Univ, Clin Med Coll 1, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Hosp, 204 West Donggang RD, Lanzhou 730000, Peoples R China.

年份：2024

卷号：47

期号：8

起止页码：3417

外文期刊名：ASIAN JOURNAL OF SURGERY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001284555600001)】；

语种：英文

外文关键词：Pancreatic cancer; D-dimer; Prognostic; Biomarker; Biomarker

摘要：According to previous studies, D-dimer levels are associated with the prognosis of patients with pancreatic cancer (PC). However, the results of current studies are limited and controversial. Therefore, we performed this meta-analysis to assess the relationship between D-dimer levels and prognostic and pathological characteristics of PC patients. We first searched the databases of PubMed, Embase, The Cochrane Library, Web Of Science, CBM, VIP, CNKI and Wanfang to identify available studies. The relationship between pretreatment d-dimer levels and prognosis in PC patients was assessed using the combined hazard ratio (HR) and 95% confidence interval (CI). The combined odds ratio (OR) and 95% confidence interval (CI) were used in assessing the relationship between pathological characteristics and d-dimer levels in PC patients. Stata 12.0 software was used for all statistical analyses. In total, we included 13 studies involving 2777 patients. The results showed that elevated pre-treatment d -dimer levels were significantly associated with OS deterioration (HR = 1.46 95% CI: 1.34-1.59; p < 0.001). We also performed subgroup analyses based on sample size, d -dimer threshold, follow-up time, and HR source to further validate the prognostic value of pretreatment d -dimer levels in PC. In addition, according to the analysis, high pretreatment d -dimer levels in PC patients were associated with late tumor stage (OR = 4.78, 95% CI 1.73-13.20, p < 0. 005), larger tumor size (OR = 1.72, 95% CI 1.25-2.35, p < 0.005), and distant metastasis of tumor (OR = 5.06, 95% CI 2.45-10.43, p <0.005) were significantly associated. In contrast, other clinicopathological factors, including age, gender and lymph node metastasis, were not associated with d-dimer levels. In conclusion, we found that high pre-treatment d-dimer levels were associated with a poor prognosis in PC patients, in relation to later tumor stage, larger tumor size and the development of distant metastases. Plasma d-dimer levels can be used as a biomarker of prognosis in PC patients. (c) 2024 Asian Surgical Association and Taiwan Society of Coloproctology. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license