文献类型：期刊文献

中文题名：三黄膏治疗局部软组织感染临床疗效观察

英文题名：Clinical Efficacy of Sanhuanggao to Treat Patients with Superficial Soft Tissue Infections

作者：潘海邦[1];吴国泰[2];易剑锋[1];王波[1];董小鹏[1];易华[3]

第一作者：潘海邦

机构：[1]甘肃中医药大学;[2]甘肃省中药药理与毒理学重点实验室;[3]甘肃中医药大学附属医院

第一机构：甘肃中医药大学

年份：2017

卷号：23

期号：20

起止页码：174

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：CSTPCD;;北大核心:【北大核心2014】；CSCD:【CSCD_E2017_2018】；

基金：甘肃省中医管理局科研项目(GZK-2011-42);甘肃省中药药理与毒理学重点实验室开放基金项目(ZDSYS-KJ-2016-007)

语种：中文

中文关键词：三黄膏;外敷;软组织感染;谷氨酸-丙酮酸氨基转移酶;天门冬氨酸氨基转移酶;尿素氮;肌酐

外文关键词：Sanhuanggao; external applying; superficial soft tissue infection; alanine aminotransferase（ALT） ; aspartate aminotransferase （AST） ; urea nitrogen （BUN） ; creatinine （Cr）

摘要：目的:观察三黄膏外敷治疗体表软组织感染的临床疗效,探讨其作用机制。方法:120例软组织感染患者随机分为三黄膏大剂量组、三黄膏小剂量组和对照组;观察治疗前后感染部位局部肿胀、红斑、疼痛、硬结、温度、脓疱或溃疡的好转情况,检测治疗前及治疗后第1,3,5,7天血常规、尿常规、肝肾功能指标谷氨酸-丙酮酸氨基转移酶(ALT),天门冬氨酸氨基转移酶(AST),尿素氮(BUN),肌酐(Cr)变化。结果:三黄膏大剂量组病程(6.93±2.74)d,小剂量组(7.75±2.93)d,对照(鱼石脂软膏)组(8.77±2.82)d,与对照组治疗后比较,三黄膏外敷明显缩短了病程(P<0.05);三黄膏使患者一般状况综合评分明显下降(P<0.05),能促进局部肿块消散,红肿消退,减轻疼痛,降低局部温度,促进脓疱及溃疡愈合;治疗后第1,3天,三黄膏大、小剂量组血常规、尿常规、肝肾功能(ALT,AST,BUN,Cr)恢复正常的人数高于对照组(P<0.05);治疗后第5,7天,各检验结果均基本恢复正常;治疗期间未见明显不良反应。结论:三黄膏对体表软组织感染具有确切治疗作用,可缩短病程,临床安全性高,值得推广。
Objective： To investigate the clinical efficacy of Sanhuanggao external applying in the treatment of superficial soft tissue infection,and explore its mechanism. Method： The 120 patients with superficial soft tissue infection were randomly divided into 3 groups： high dose Sanhuanggao group,low dose Sanhuanggao group and ichthammol ointment group. The changes of local swelling,redness,pain,induration,temperature,pustular or ulcer were observed; the numerical value of blood routine,urine routine,and the indexes of liver and kidney function,including alanine aminotransferase（ ALT）,aspartate aminotransferase（ AST）,urea nitrogen（ BUN）,creatinine（ Cr） in blood were recorded before and after 1,3,5,7 thdays. Result： As compared with ichthammol ointment group,Sanhuanggao external applying significantly shortened the course of disease. The course of disease was（ 6. 93 ± 2. 74） d in large dose Sanhuanggao group,（ 7. 75 ± 2. 93） d in small dose group,and（ 8. 77 ± 2. 82） d in ichthammol ointment group（ P〈0. 05）. The external application of Sanhuanggao decreased the comprehensive score of the general situation significantly（ P〈0. 05）,promote the local mass dissipation,remove swelling,relieve pain,reduce the local temperature,and promote pustules and ulcer healing. The numbers of people whose blood and urine routine indexes as well as the liver and kidney functions（ ALT,AST,BUN,Cr）returned to normal in large and small dosage Sanhuanggao groups were higher significantly than those in the control group after treatment on day 1 and day 3（ P〈0. 05）; on day 5 and day 7 after treatment,the test results basically returned to normal,without obvious adverse reactions during treatment. Conclusion： Sanhuanggao has definite clinical efficacy in treatment of superficial soft tissue infection,which can shorten the course of disease with high clinical safety,so it is worthy of clinical promotion.