文献类型：期刊文献

英文题名：EPO rs1617640 A>C is a Protective Factor for Chronic Obstructive Pulmonary Disease: A Case Control Study

作者：Wang, Yunchao[1];Li, Zhi[2];Zhang, Xiaoyi[1];Lin, Ao[2];Chen, Cuiyi[3];Zeng, Xiaobin[2];Pan, Yujie[2];Mao, Chun[2];Xie, Chenli[4];Huang, Dongsheng[5];Deng, Yibin[6];Zhang, Xuhui[7];Lu, Jiachun[2];Wang, Xinhua[1]

第一作者：Wang, Yunchao

通信作者：Wang, XH[1];Lu, JC[2]

机构：[1]Gansu Univ Chinese Med, Inst Basic Med, Inst Publ Hlth, Lanzhou 730000, Gansu, Peoples R China;[2]Guangzhou Med Univ, Affiliated Hosp 1, Inst Publ Hlth, State Key Lab Resp Dis, Guangzhou 511436, Guangdong, Peoples R China;[3]SSL Cent Hosp Dongguan City, Dept Resp Med, Dongguan 523326, Guangdong, Peoples R China;[4]Dongguan Binwan Cent Hosp, Dept Resp & Crit Care Med, Dongguan 523903, Guangdong, Peoples R China;[5]Shenzhen Longhua Dist Cent Hosp, Dept Resp & Crit Care Med, Shenzhen 518110, Guangdong, Peoples R China;[6]Youjiang Med Univ Nationalities, Affiliated Hosp, Ctr Med Lab Sci, Baise 533099, Guangxi, Peoples R China;[7]Gansu Univ Chinese Med, Affiliated Hosp, Dept Resp Med, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Inst Basic Med, Inst Publ Hlth, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Guangzhou Med Univ, Affiliated Hosp 1, Inst Publ Hlth, State Key Lab Resp Dis, Guangzhou 511436, Guangdong, Peoples R China.|[10735]甘肃中医药大学;

年份：2023

卷号：28

期号：9

外文期刊名：FRONTIERS IN BIOSCIENCE-LANDMARK

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001116676900018)】；

基金：This study was supported by the following grants: National Key Research and Development Project of China 2017YFC0907202 (Xinhua Wang) ; National Natural Science Foundation of China 81872694, 82173609 (Jiachun Lu) ; Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program 2017BT01S155 (Jiachun Lu) ; Guangdong Medical Science and Technology Research Fund Project A2020324 (Cuiyi Chen) ; National Natural Science Foundation of China (81460123) and Guangxi Natural Foundation (2018GXNSFAA281187) (Yibin Deng) ; National Natural Science Foundation of China (82260889) (Xuhui Zhang) ; the Science and Technology Project of Guangzhou (No.202103000073) .

语种：英文

外文关键词：COPD; EPO; polymorphism; susceptibility; absolute risk

摘要：Background: The occurrence and development of chronic obstructive pulmonary disease (COPD) are regulated by environmental and genetic factors. In hypoxia, Erythropoietin (EPO) satisfies the body's need for oxygen by promoting the production of red blood cells. Hypoxia was proven to be a common physiological condition in COPD progression and associated with many complications. Some studies have found that EPO is involved in the development of COPD. But the mechanism has not been fully proven. Methods: We conducted a case-control study enrolled 1095 COPD patients and 1144 healthy controls in Guangdong Province to evaluate the association between EPO polymorphisms (rs1617640 A>C, rs507392 A>G, rs564449 G>T) and COPD susceptibility. 872 participants from southern Gansu Province were recruited to verify the effect of EPO polymorphisms on lung function. Results: EPO rs1617640 C allele reduced COPD susceptibility in southern Chinese significantly (AC vs. AA: adjusted Odds ratio (OR) = 0.805, 95% CI = 0.669-0.969; AC+CC vs. AA: adjusted OR = 0.822, 95% CI = 0.689-0.980). However, there was no association between rs507392 A>G and rs564449 G>T polymorphisms and COPD susceptibility (p > 0.05). We further observed that the rs1617640 C allele was associated with higher FEV1 and FVC in Guangdong and Gansu populations significantly (both p < 0.05). In brief, the level of FEV1 and FVC increased with the C allele number. We modeled the relative risk for men and women, in which the population-attributable risks chances were 0.449 (0.258-0.641) and 0.262 (0.128-0.396) respectively. In this model, smoking status, coal as fuels, education level, and rs1617640 A>C were finally retained for males, while smoking status, biomass as fuels, and1617640 A>C were retained for females. In the end, using the method developed by Gail and Bruzzi, we fitted a 10-year absolute risk model for southern Chinese with different individual relative risks, which was presented as a table. Conclusions: In conclusion, this study found that EPO rs1617640 A>C polymorphism is associated with COPD susceptibility in southern Chinese, and the C allele was associated with better lung function. In addition, it could also be considered a genetic marker associated with environmental factors to predict the absolute 10-year risk of COPD in southern Chinese.