文献类型：期刊文献

中文题名：从“虚”论治激素性股骨头坏死与OPG/RANK/RANKL系统相关性研究进展

英文题名：Research Progress in Relationship Between Treating Steroid-induced Osteonecrosis of Femoral Head by Deficiency and OPG/RANK/RANKL

作者：曹林忠[1,2];张晓刚[1,2];赵希云[1];宋敏[1];张宏伟[1];秦大平[1];汪小敏[1]

第一作者：曹林忠

机构：[1]甘肃中医药大学;[2]甘肃中医药大学附属医院

第一机构：甘肃中医药大学

年份：2017

卷号：24

期号：4

起止页码：123

中文期刊名：中国中医药信息杂志

外文期刊名：Chinese Journal of Information on Traditional Chinese Medicine

收录：CSTPCD;;CSCD:【CSCD_E2017_2018】；

基金：国家自然科学基金(81560780);甘肃省自然科学基金(1308RJZA293);甘肃省中药现代制造工程研究院项目(YWW-2015049)

语种：中文

中文关键词：激素性股骨头坏死;OPG/RANK/RANKL系统;脾肾亏虚;综述

外文关键词：steroid-induced osteonecrosis of femoral head; OPG/RANK/RANKL system; spleen and kidney deficiency; review

摘要：近年研究表明,中医药治疗骨代谢疾病如激素性股骨头坏死疗效确切,受到广泛关注,但由于缺乏药效机制的分子生物学依据,尚未达到科学标准化治疗水平。OPG/RANK/RANKL系统的发现成为骨代谢疾病防治及研究的新切入点,激素性股骨头坏死"脾肾亏虚-由痰致瘀-因瘀致痹"的病机演变与该系统密切相关,从"虚"论治的效应最终可通过该系统轴向调控的微观信息来表达。本文初步探讨激素性股骨头坏死的中医辨治,并结合OPG/RANK/RANKL系统对骨代谢的调控机制阐述其相关性,为该病的防治及后续研究提供依据。
Recent studies have shown that TCM treatment for bone metabolic diseases,such as steroid-inducedavascular necrosis of the femoral head,has definite efficacy and has received extensive attention.However,due tolack of molecular biological basis of pharmacodynamics mechanism,it has not yet reached the standard of scientifictreatment.The discovery of OPG/RANK/RANKL system has become a new breakthrough point in the prevention andtreatment of bone metabolic diseases.The pathogenesis of“deficiency of spleen and kidney-blood stasis-caused byphlegm arthralgia caused by blood stasis”is closely related to the system.The effect of the final control of the systemfrom the“deficiency”theory can be expressed through the axial micro-information.This article discussed the TCMsyndrome differentiation of steroid-induced osteonecrosis of the femoral head and the relation of regulation of bonemetabolism combined with the OPG/RANK/RANKL system,and provided the basis for prevention and treatment ofthis disease.