文献类型：期刊文献

英文题名：Significance of nicotine and nicotinic acetylcholine receptors in Parkinson's disease

作者：Lin, Xia[1];Li, Qian[2];Pu, Min[2];Dong, Hao[2];Zhang, Qinghua[1]

第一作者：Lin, Xia

通信作者：Zhang, QH[1]

机构：[1]First Peoples Hosp Tianshui, Dept Neurol, Tianshui, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Clin Med Sch 1, Lanzhou, Gansu, Peoples R China

第一机构：First Peoples Hosp Tianshui, Dept Neurol, Tianshui, Gansu, Peoples R China

通信机构：[1]corresponding author), First Peoples Hosp Tianshui, Dept Neurol, Tianshui, Gansu, Peoples R China.

年份：2025

卷号：17

外文期刊名：FRONTIERS IN AGING NEUROSCIENCE

收录：;Scopus(收录号：2-s2.0-105001705945);WOS:【SCI-EXPANDED(收录号:WOS:001458528400001)】；

基金：The author(s) declare that no financial support was received for the research and/or publication of this article.

语种：英文

外文关键词：Parkinson's disease (PD); neurodegeneration; nicotine; nicotinic acetylcholine receptors; alpha-synuclein

摘要：Parkinson's disease (PD) is a multifaceted neurodegenerative disorder characterized by the degeneration of dopaminergic neurons in the substantia nigra and the aggregation of alpha-synuclein. According to epidemiological data, PD is the second most prevalent neurodegenerative disorder after Alzheimer's disease (AD) and has emerged as a significant global health concern. This review examines the intricate pathological mechanisms and high-risk factors associated with PD, and discusses the challenges in its clinical diagnosis and treatment. We elucidate the relationship between smoking and the reduced risk of PD, highlighting the potential neuroprotective effects of nicotine present in tobacco. The interaction between nicotine and nicotinic acetylcholine receptors (nAChRs) is analyzed in detail, emphasizing their neuroprotective capabilities and underlying molecular mechanisms. Furthermore, we analyze the structural and functional diversity of nAChRs and their roles in the pathological progression of PD. Our review aims to elucidate the complex interplay of genetic, environmental, and biochemical factors in PD and to propose future research directions that may facilitate therapeutic development.