文献类型：期刊文献

中文题名：NLRP3炎症小体与细胞焦亡在糖尿病肾病中的作用机制研究进展

英文题名：Research Pogress on Action Mechanism of NLRP3 Inflammasome and Pyroptosis in Diabetic Nephropathy

作者：雷震云[1];薛国忠[1];刘臻华[1,2];张新丽[3]

第一作者：雷震云

机构：[1]甘肃中医药大学附属医院肾病科,兰州730000;[2]甘肃中医药大学,兰州730000;[3]甘肃省中医院肾病科,兰州730000

第一机构：甘肃中医药大学第二附属医院

年份：2025

卷号：16

期号：3

起止页码：722

中文期刊名：协和医学杂志

外文期刊名：Medical Journal of Peking Union Medical College Hospital

收录：;北大核心:【北大核心2023】；

基金：国家自然科学基金地区项目(82160865);甘肃中医药大学附属医院院内科研基金项目(gzfy-2021-06)。

语种：中文

中文关键词：糖尿病肾病;NLRP3炎症小体;细胞焦亡;免疫激活;作用机制

外文关键词：diabetic nephropathy;NLRP3 inflammasome;pyroptosis;immune activation;mechanism of action

摘要：糖尿病肾病(diabetic nephropathy,DN)作为糖尿病常见的并发症之一,是导致终末期肾病的主要原因。DN的发病机制包括慢性炎症、免疫细胞募集与激活、肾小管与肾小球损伤以及肾脏纤维化等过程,而这些过程与核苷酸结合寡聚化结构域样受体蛋白3(nucleotide-binding oligomerization domain-like receptor protein 3,NLRP3)炎症小体的激活及其所介导的细胞焦亡高度相关。既往研究表明,通过调控NLRP3炎症小体及其介导的细胞焦亡,可减少促炎因子的释放、损伤相关分子模式的泄漏、免疫细胞的募集和激活,从而减缓邻近细胞的炎症反应扩散、纤维化和组织重塑过程,并最终改善DN引起的肾脏损伤和功能障碍。本文通过综述NLRP3炎症小体及其介导的细胞焦亡在DN不同病理阶段中的分子调控机制,提出调控其激活的潜在靶点,以期为DN的个性化治疗提供新方向。
Diabetic nephropathy(DN),as one of the most common complications of diabetes,is a primary cause of end-stage renal disease.The pathogenesis of DN encompasses processes such as chronic inflammation,recruitment and activation of immune cells,tubular and glomerular injury,and renal fibrosis.These processes are highly correlated with the activation of the nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3(NLRP3)inflammasome and the resulting pyroptosis it mediates.Previous studies have shown that the release of pro-inflammatory cytokines,leakage of damage-associated molecular patterns(DAMPs),recruitment and activation of immune cells can be reduced by regulating the NLRP3 inflammasome and its mediated pyroptosis,thereby slowing the diffusion of inflammatory responses in adjacent cells,fibrosis,and tissue remodeling processes.Ultimately,these process can improve renal injury and dysfunction caused by diabetic nephropathy.This article summarizes the molecular regulatory mechanisms of the NLRP3 inflammasome and its mediated pyroptosis at different pathological stages of DN,proposes potential targets for regulating their activation,aiming to provide a new direction for personalized treatment of DN.