文献类型：期刊文献

中文题名：扶元补脑冲剂对实验小鼠记忆的影响

英文题名：Effect of Fuyuanbunao Granules on Memory of Experimental Mice

作者：刘永琦[1];何建成[1];刘雄[1];徐厚谦[1];史正刚[1]

第一作者：刘永琦

机构：[1]甘肃中医学院,甘肃兰州730000

第一机构：甘肃中医药大学

年份：2001

卷号：23

期号：2

起止页码：115

中文期刊名：中成药

外文期刊名：Chinese Traditional Patent Medicine

收录：CSTPCD;;北大核心:【北大核心2000】；CSCD:【CSCD2011_2012】；

语种：中文

中文关键词：扶元补脑冲剂;记忆;急性毒性;试验;小鼠

外文关键词：Fuyuanbunao Granules; memory; acute toxicity test

摘要：目的 :探讨和揭示扶元补脑冲剂健脑益智作用及有无毒副反应等 ,揭示扶元补脑冲剂健脑益智的作用机理。方法 :观察了扶元补脑冲剂对戊巴比妥钠、樟柳碱造成的记忆获得障碍 ,对亚硝酸钠造成的记忆巩固障碍 ,对乙醇造成的记忆再现障碍的影响 ,并进行了急性毒性试验。结果 :该制剂对上述因素造成的记忆障碍均有较明显的改善作用 ,且此作用与剂量有关。剂量较大时作用越明显。急性毒性试验未见动物死亡和出现明显毒副作用。结论 :扶元补脑冲剂可能具有胆碱能样作用 ,可以促进需氧代谢 ,改善脑缺氧 ,对抗中枢神经系统的抑制状态。该制剂毒性甚小 ,可以提供临床使用。
Objective: To probe and reveal the brain tomic and the wise sharpening action of Fuyuanbunao Granules and Its toxicity and side effect. Methods: The effects of Fuyuanbunao Granules on the memory acquisition disturbance induced by pentobarbital sodium or anisodine, the memory consolidation disturbance induced by sodium nitrite, and the memory repetition disturbance induced by alcohol were observed. Meanwhile, the acute toxicity test was done. Results: The granules could obriously improve the memory disturbance induced by the factors obove, and the improvement effect varied with the dose. The effects of larger dose groups were more obvious. There were no death of animals or toxicity and sile effect in test. Conclusion:Fuyuanbunao Granules maybe have the cholinergic acction. It can promote the aerobic metabolism, improve the cerebral anoxia and the inhibited state of center nervous system. It has low toxicity and can be used in clinical application.