文献类型：期刊文献

英文题名：Important Role of Mitochondrial Dysfunction in Immune Triggering and Inflammatory Response in Rheumatoid Arthritis

作者：Li, Pingshun[1,2];Zhou, Mengru[2];Wang, Jia[2];Tian, Jiexiang[2];Zhang, Lihuan[2];Wei, Yong[2];Yang, Fang[2];Xu, Yali[1];Wang, Gang[2]

第一作者：Li, Pingshun

通信作者：Wang, G[1]

机构：[1]Gansu Univ Chinese Med, Coll Integrat Chinese & Western Med, Lanzhou 730000, Peoples R China;[2]Gansu Univ Chinese Med, Affiliated Hosp, Dept Rheumatol & Bone Dis, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Affiliated Hosp, Dept Rheumatol & Bone Dis, Lanzhou 730000, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2024

卷号：17

起止页码：11631

外文期刊名：JOURNAL OF INFLAMMATION RESEARCH

收录：;Scopus(收录号：2-s2.0-85215293250);WOS:【SCI-EXPANDED(收录号:WOS:001396829900001)】；

基金：Supported by the National Natural Science Foundation of China Regional projects (No. 81860858, 81960832) ,the Gansu Provincial Natural Science Foundation Youth Fund Program (No.22JR11RA133, 21JR11RA158, 23JRRA1584, 24JRRA548) , The Second Affiliated Hospital of Gansu University of Traditional Chinese Medicine Youth Program (No. ZX-62000004-2022-092) ,Gansu Province Famous Traditional Chinese Medicine Practitioners Inheritance Studio Construction Project (National TCM Regulation and Caixin Letter [2021] No. 50) and 2023 Central Finance Transfer Payment for Local Projects for Capacity Enhancement of Chinese Medicine Counseling and Evidence Construction (No. 2101704) .

语种：英文

外文关键词：mitochondria; rheumatoid arthritis; immune triggers; inflammatory response; osteoblasts; synovial cells

摘要：Rheumatoid arthritis (RA) is an inflammatory autoimmune disease, primarily characterized by chronic symmetric synovial inflammation and erosive bone destruction.Mitochondria, the primary site of cellular energy production, play a crucial role in energy metabolism and possess homeostatic regulation capabilities. Mitochondrial function influences the differentiation, activation, and survival of both immune and non-immune cells involved in RA pathogenesis. If the organism experiences hypoxia, genetic predisposition, and oxidative stress, it leads to mitochondrial dysfunction, which further affects immune cell energy metabolism, synovial cell proliferation, apoptosis, and inflammatory signaling, causing the onset and progression of RA; and, mitochondrial regulation is becoming increasingly important in the treatment of RA.In this review, we examine the structure and function of mitochondria, analyze the potential causes of mitochondrial dysfunction in RA, and focus on the mechanisms by which mitochondrial dysfunction triggers chronic inflammation and immune disorders in RA. We also explore the effects of mitochondrial dysfunction on RA immune cells and osteoblasts, emphasizing its key role in the immune response and inflammatory processes in RA. Furthermore, we discuss potential biological processes that regulate mitochondrial homeostasis, which are of great importance for the prevention and treatment of RA.