文献类型：期刊文献

中文题名：中药治疗脾胃湿热型慢性萎缩性胃炎临床应用及作用机制研究进展

英文题名：Research progress in the clinical application and mechanisms of Chinese materia medica in treating chronic atrophic gastritis of spleen-stomach damp-heat syndrome

作者：苏李宁[1];刘俊宏[2];王丹[1];张金雪[1];李红梅[1];徐冰蕊[1];陈佳乐[1];何渝蝶[3]

第一作者：苏李宁

机构：[1]甘肃中医药大学中西医结合学院,兰州730030;[2]甘肃中医药大学附属医院脾胃病科,兰州730099;[3]重庆市北碚区中医院,重庆400700

第一机构：甘肃中医药大学中西医结合学院

年份：2025

卷号：47

期号：12

起止页码：1792

中文期刊名：国际中医中药杂志

外文期刊名：International Journal of Traditional Chinese Medicine

基金：国家中医药管理局青年岐黄学者基金项目(国中医药人教函〔2022〕256号);甘肃省临床医学研究中心建设项目(21JR7RA682);甘肃省科技厅重点研发计划(22YFTFA100);2022年省级重点人才项目和陇原青年创新创业人才项目(2022RCXM020);甘肃省中医药管理局重点项目(GZKZ-2021-6)。

语种：中文

中文关键词：胃炎,萎缩性;脾胃湿热证;中药;临床应用;作用机制;综述

外文关键词：Gastritis,atrophic;Spleen-stomach damp-heat syndrome;Chinese materia medica;Clinical application;Mechanism;Review

摘要：脾胃湿热证为慢性萎缩性胃炎(CAG)的主要证型,胃内湿热状态被认为是病程缠绵不愈的关键因素,而脾胃湿热是CAG整体病机演变过程中趋深入化的关键环节。现代中医多认为,脾胃湿热型CAG核心病机为“本虚标实、湿热内蕴”,治疗以祛邪兼顾扶正、动态辨治等为侧重点。临床应用中药内服治疗脾胃湿热型CAG,可缓解患者临床症状,改善湿热内环境、减轻胃黏膜萎缩及异型增生,延缓“炎癌转化”进程,作用机制可能涉及清除Hp、修复胃黏膜损伤、调控免疫炎症反应等方面,具有多途径、多靶点优势。
Spleen-stomach damp-heat syndrome is currently the most prevalent TCM pattern in patients with chronic atrophic gastritis(CAG),with internal damp-heat accumulation regarded as a key factor contributing to its prolonged and refractory course.This syndrome represents a critical stage in the progressive pathogenesis of CAG,characterized by a deepening pathological evolution.Modern TCM practitioners generally agree that its core pathogenesis lies in"deficiency in root and excess in superficiality,with internal damp-heat retention",and emphasize a treatment strategy that combines eliminating pathogenic factors and reinforcing the body's healthy qi through dynamic syndrome differentiation.Chinese materia medica used in treating CAG with spleen-stomach damp-heat syndrome can effectively relieve clinical symptoms,improve the internal damp-heat environment,mitigate gastric mucosal atrophy and intestinal metaplasia,and delay the inflammation-to-cancer transformation.Its mechanisms may involve eradication of Helicobacter pylori,repair of gastric mucosal injury,regulation of immune inflammatory response and other aspects,which has the advantages of multi-channel and multi-target.