文献类型：期刊文献

英文题名：Mechanism of Action of the Plateau-Adapted Gene PPARA in COPD

作者：Li, Honge[1];Pei, Wenhui[1];Wang, Yunchao[2];Zhang, Yuhuan[1];Yang, Zhen[1];Wang, Xinhua[1]

第一作者：何黎

通信作者：Wang, XH[1]

机构：[1]Gansu Univ Chinese Med, Inst Publ Hlth, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Inst Basic Med, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Inst Publ Hlth, Lanzhou 730000, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2024

卷号：29

期号：2

外文期刊名：FRONTIERS IN BIOSCIENCE-LANDMARK

收录：;Scopus(收录号：2-s2.0-85186616332);WOS:【SCI-EXPANDED(收录号:WOS:001175634000010)】；

基金：This study was supported by the following grant: National Key Research and Development Project of China 2017YFC0907202.

语种：英文

外文关键词：PPARA; chronic obstructive pulmonary disease; plateau adaptation genes; inflammatory response; oxidative stress reaction; lipid metabolism

摘要：Chronic obstructive pulmonary disease (COPD) is a complex respiratory disorder influenced by various factors and involving multiple genes. Respiratory dysfunction in COPD patients leads to hypoxia, resulting in limited oxygen uptake. Peroxisome proliferator-activated receptor alpha (PPARA) is a plateau-adapted gene that regulates respiratory function in populations adapted to high-altitude areas through multiple pathways. Interestingly, PPARA expression is higher in long-term inhabiting Tibetan populations that have adapted to the plateau environment. However, in patients with COPD, the expression of PPARA is downregulated, leading to dysregulation of the hypoxiainducible factor pathway. Moreover, abnormal PPARA expression in lung epithelial cells triggers inflammatory responses, oxidative stress, and disrupted lipid metabolism, thereby exacerbating disease progression. Thus, this paper explored the mechanism underlying the role of plateau-adapted PPARA in COPD, providing essential theoretical insights into the treatment and prevention of COPD in high-altitude regions.