文献类型：期刊文献

英文题名：Formal Asymmetric Synthesis of (-)-Cephalotaxine, (-)-Cephalotine B and (-)-Fortuneicyclidin A/B

作者：Zhang, Qing-kang[1,2];Zan, Xi-zhan[1,2];Zhang, Yi-fu[1,2];Zheng, Yu-jie[1,2];Song, Jia-liang[1,2];Xie, Yong-qiang[1,3];Wu, Guo-tai[1,2];Wu, Xue-lian[1,2];Zhang, Jian[1,2,3];Zhang, Zhi-wei[4]

第一作者：Zhang, Qing-kang

通信作者：Zhang, J[1];Zhang, J[2];Zhang, J[3]

机构：[1]Gansu Univ Chinese Med, Sch Pharm, Lanzhou 730000, Peoples R China;[2]Northwest Collaborat Innovat Ctr Tradit Chinese Me, Lanzhou 730000, Peoples R China;[3]Gansu Univ Chinese Med, Expt & Training Teaching Ctr Inst, Lanzhou 730000, Peoples R China;[4]Hebei Univ Sci Technol, Coll Chem & Pharmaceut Engn, Shijiazhuang 050018, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Pharm, Lanzhou 730000, Peoples R China;[2]corresponding author), Northwest Collaborat Innovat Ctr Tradit Chinese Me, Lanzhou 730000, Peoples R China;[3]corresponding author), Gansu Univ Chinese Med, Expt & Training Teaching Ctr Inst, Lanzhou 730000, Peoples R China.|[10735]甘肃中医药大学;

年份：2026

外文期刊名：JOURNAL OF ORGANIC CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001800614200001)】；

基金：This work was supported by the Educational Science and Technology Innovation Program of Gansu Province (2024QB-086, 2026QB-064, 2026CXZX-953), the Key Research and Development Plan for Universities in Hebei Province (241200103A), and the National Natural Science Foundation of China (21562001).

语种：英文

摘要：Asymmetric Stevens rearrangement of chiral aza-quaternary ammonium salts, synthesized from Weinreb amides using alkyl triflates, enables efficient construction of the chiral quaternary carbon centers. This method, featuring subsequent functional group transformations, allows for the concise asymmetric synthesis of (-)-cephalotaxine, (-)-cephalotine B, (-)-fortuneicyclidin A, and (-)-fortuneicyclidin B. This study enables a more concise and efficient implementation of the asymmetric Stevens rearrangement, thereby facilitating its application in the asymmetric synthesis of complex alkaloid molecules.