文献类型：期刊文献

英文题名：Hepcidin: A Promising Therapeutic Target for Iron Disorders A Systematic Review

作者：Liu, Jing[1];Sun, Bingbing[2];Yin, Huijun[3,4];Liu, Sijin[1]

第一作者：Liu, Jing

通信作者：Liu, SJ[1];Yin, HJ[2]

机构：[1]Chinese Acad Sci, State Key Lab Environm Chem & Ecotoxicol, Res Ctr Ecoenvironm Sci, 18 Shuangqing Rd, Beijing 100085, Peoples R China;[2]Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA;[3]China Acad Chinese Med Sci, Beijing Xiyuan Hosp, Dept Cardiovasc Dis, Beijing 100091, Peoples R China;[4]Gansu Univ Tradit Chinese Med, Lanzhou, Peoples R China

第一机构：Chinese Acad Sci, State Key Lab Environm Chem & Ecotoxicol, Res Ctr Ecoenvironm Sci, 18 Shuangqing Rd, Beijing 100085, Peoples R China

通信机构：[1]corresponding author), Chinese Acad Sci, State Key Lab Environm Chem & Ecotoxicol, Res Ctr Ecoenvironm Sci, 18 Shuangqing Rd, Beijing 100085, Peoples R China;[2]corresponding author), China Acad Chinese Med Sci, Beijing Xiyuan Hosp, Dept Cardiovasc Dis, Beijing 100091, Peoples R China.

年份：2016

卷号：95

期号：14

外文期刊名：MEDICINE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000375257000015)】；

基金：This study was supported by a grant under the national "973'' program (grant number: 2014CB932000), the Strategic Priority Research Program of the Chinese Academy of Sciences (Grant No. XDB14000000), and grants from the National Natural Science Foundation of China (grant numbers: 21425731, 21377159, 91543124).

语种：英文

摘要：Iron is required for most forms of organisms, and it is the most essential element for the functions of many iron-containing proteins involved in oxygen transport, cellular respiration, DNA replication, and so on. Disorders of iron metabolism are associated with diverse diseases, including anemias (e.g., iron-deficiency anemia and anemia of chronic diseases) and iron overload diseases, such as hereditary hemochromatosis and beta-thalassemia. Hepcidin (encoded by Hamp gene) is a peptide hormone synthesized by hepatocytes, and it plays an important role in regulating the systematic iron homeostasis. As the systemic iron regulator, hepcidin, not only controls dietary iron absorption and iron egress out of iron storage cells, but also induces iron redistribution in various organs. Deregulated hepcidin is often seen in a variety of iron-related diseases including anemias and iron overload disorders. In the case of iron overload disorders (e.g., hereditary hemochromatosis and beta-thalassemia), hepatic hepcidin concentration is significantly reduced. Since hepcidin deregulation is responsible for iron disorder-associated diseases, the purpose of this review is to summarize the recent findings on therapeutics targeting hepcidin. Continuous efforts have been made to search for hepcidin mimics and chemical compounds that could be used to increase hepcidin level. Here, a literature search was conducted in PubMed, and research papers relevant to hepcidin regulation or hepcidin-centered therapeutic work were reviewed. On the basis of literature search, we recapitulated recent findings on therapeutic studies targeting hepcidin, including agonists and antagonists to modulate hepcidin expression or its downstream signaling. We also discussed the molecular mechanisms by which hepcidin level and iron metabolism are modulated. Elevating hepcidin concentration is an optimal strategy to ameliorate iron overload diseases, and also to relieve beta-thalassemia phenotypes by improving ineffective erythropoiesis. Relative to the current conventional therapies, such as phlebotomy and blood transfusion, therapeutics targeting hepcidin would open a new avenue for treatment of iron-related diseases.