文献类型：期刊文献

中文题名：活血定眩胶囊治疗椎动脉型颈椎病临床疗效评价

英文题名：Clinical Effects Evaluation of Huoxue Dingxuan Capsules in Treatment of Vertebral Artery Type of Cervical Spondylosis

作者：董万涛[1];宋敏[2];吕泽斌[3];安文博[1];温孝明[1];蒋宜伟[2];陈秉雄[2];柴居堂[2]

第一作者：董万涛

机构：[1]甘肃中医学院附属医院;[2]甘肃中医学院;[3]成都中医药大学

第一机构：甘肃中医药大学第二附属医院

年份：2014

卷号：21

期号：1

起止页码：33

中文期刊名：中国中医药信息杂志

外文期刊名：Chinese Journal of Information on Traditional Chinese Medicine

收录：CSTPCD;;CSCD:【CSCD_E2013_2014】；

基金：国家自然科学基金(81360554);甘肃省重点中医药科研项目(GZK-2010-Z14);甘肃省高校研究生导师科研项目(1206-01)

语种：中文

中文关键词：椎动脉型颈椎病;活血定眩胶囊;随机对照试验;临床疗效评价

外文关键词：vertebral artery type of cervical spondylosis; Huoxue Dingxuan Capsule;randomized controlled trial; clinical effects evaluation

摘要：目的观察活血定眩胶囊治疗椎动脉型颈椎病的临床疗效,评价其有效性和安全性。方法将130例椎动脉型颈椎病患者随机分为治疗组和对照组,分别口服活血定眩胶囊、西比灵胶囊治疗。采用积分法比较2组主要症状、体征改善的差异,评定总体疗效及安全性,并随访观察6个月后复发情况。结果 2种治疗方法对于椎动脉型颈椎病症状、体征的改善均有显著疗效,治疗组总有效率94.03﹪(63/67),对照组82.54﹪(52/63),治疗组总体疗效及在缓解症状、体征方面优于对照组(P<0.01)。2组治疗后平均血流速度均有显著变化(P<0.05),但治疗组效果明显优于对照组(P<0.01)。治疗组6个月内症状、体征有轻度复发者4例(6.34﹪),对照组18例(34.61﹪),组间差异有统计学意义(P<0.01);未见重度复发者。2组均未见药物不良反应发生。结论活血定眩胶囊治疗椎动脉型颈椎病安全、有效,其远期疗效和受试者依从性优于口服西比灵胶囊。
Objective To observe the clinical effects of Huoxue Dingxuan Capsules on treatment of vertebral artery type of cervical spondylosis, and evaluate its efficacy and safety. Methods Totally 130 cases of vertebral artery type of cervical spondylosis were randomly assigned to treatment group and control group, and treated with Huoxue Dingxuan Capsules and Sibelium capsules respectively. Integration method was used to compare the differences of main symptoms and signs, the overall efficacy and safety were evaluated, and relapse after six months was followed up. Results Both groups had a significant effect on the improvement of signs and symptoms in vertebral artery type of cervical spondylosis, the total efficiency was 94.03% （63/67） in treatment group and 82.54% （52/63） in control group. The treatment group had a better effect on the overall efficacy and relieving symptoms and signs compared with the control group （P〈0.01）. The mean blood flow velocity had a significant change after treatment （P 〈 0.05）, and the treatment group was better than the control group （P 〈0.01）. Within six months, the treatment group had 4 cases （6.34%） with mild recurrence of symptoms and signs, and the control group had 18 cases （34.61%）, the difference between the two groups was statistically significant （P〈0.05）, and no severe recurrence was found. The two groups showed no side effects. Conelusion Huoxue Dingxuan Capsules is safe and effective for treating vertebral artery type of cervical spondylosis, and the long-term efficacy and subjects＇ compliance are better than oral Sibelium capsules.