文献类型：期刊文献

中文题名：高乌头炮制品质量标准研究

英文题名：Quality standard of processed Aconitum sinomontanum Nakai

作者：张立军[1];戴海蓉[1];李芸[1];樊秦[2];夏鹏飞[2]

第一作者：张立军

机构：[1]甘肃中医药大学,兰州730000;[2]甘肃省中藏药化学与质量研究省级重点实验室,兰州730000

第一机构：甘肃中医药大学

年份：2018

卷号：33

期号：2

起止页码：675

中文期刊名：中华中医药杂志

外文期刊名：China Journal of Traditional Chinese Medicine and Pharmacy

收录：CSTPCD;;北大核心:【北大核心2017】；CSCD:【CSCD2017_2018】；

基金：国家自然科学基金项目(No.81560650);甘肃省自然科学基金项目(No.1107RJZA242)~~

语种：中文

中文关键词：高乌头;炮制品;质量标准;薄层色谱;高效液相色谱;高乌甲素;冉乌头碱

外文关键词：Aconitum sinomontanum Nakai; Processed product; Quality standard; TLC; HPLC; Lappacontine;Ranaconitine

摘要：目的:建立高乌头炮制品质量标准,提高其质量控制水平。方法:采用性状、TLC对高乌头炮制品进行定性鉴别;采用HPLC对其有效成分进行含量测定;采用药典方法测定其水分、灰分和浸出物。结果:高乌头炮制品薄层色谱斑点清晰,分离度好;暂定其炮制品药材水分、总灰分及酸不溶性灰分分别不得过12.5%、10.9%、5.3%,水溶性浸出物和醇溶性浸出物应分别≥24.8%、21.8%;高乌头炮制品中冉乌头碱与高乌甲素的含量应≥0.059%、0.438%。结论:该研究所建立的方法准确可靠,可用于高乌头炮制品质量控制和评价。
Objective：To establish the quality standard of processed Aconitum sinomontanum Nakai,and improve its quality control level.Methods：Qualitative identification of processed Aconitum sinomontanum Nakai were identified by characters and TLC.High performance liquid chromatography（HPLC） was used for the content determination.At the same time,the moisture,ash and extractives were detected according to the pharmacopeia methods.Results：The TLC showed the spots developed clearly and the separation was good.The moisture,total ash and acid insoluble ash of processed Aconitum sinomontanum Nakai were not more than 12.5%,10.9% and 5.3% respectively.Water soluble extract and alcohol soluble extract should be no less than 24.8% and 21.8%,respectively.The ranaconitine and lappacontine of processed products were not less than 0.059% and 0.438%,respectively.Conclusion：The method established by this research institute was accurate and reliable,and could be used for quality control and evaluation of processed Aconitum sinomontanum Nakai.