文献类型：期刊文献

中文题名：经典名方四物汤化学成分、药理作用、临床应用研究进展及质量标志物预测分析

英文题名：Research Progress on Chemical Constituents,Pharmacological Effects and Clinical Application of Classic Prescription on Siwu Decoction(四物汤)and Predictive Analysis on Its Q-Markers

作者：房敏[1];赵冠宇[1];李泉洋[1];孟子盈[1];杨倩倩[1];杜丽东[1,2,3];吴国泰[1,2,3]

第一作者：房敏

机构：[1]甘肃中医药大学药学院,甘肃兰州730000;[2]甘肃省中药药理与毒理学重点实验室,甘肃兰州730000;[3]陇药产业创新研究院,甘肃兰州730000

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

年份：2024

卷号：42

期号：7

起止页码：154

中文期刊名：中华中医药学刊

外文期刊名：Chinese Archives of Traditional Chinese Medicine

收录：CSTPCD;;北大核心:【北大核心2023】；

基金：国家自然科学基金项目(82260772);甘肃中医药大学研究生创新创业基金项目(2023CX09)。

语种：中文

中文关键词：四物汤;质量标志物;化学成分;药理作用;临床应用;质量控制

外文关键词：Siwu Decoction(四物汤);quality Marker;chemical composition;pharmacological action;clinical application;quality control

摘要：四物汤出自唐代蔺道人《仙授理伤续断秘方》,是养血补血的经典名方,具有促进骨髓造血、促进红细胞生成、修复肝损伤、抗氧化、提高学习记忆能力、改善代谢和雌激素样作用,临床常用于治疗贫血,在妇科、骨伤科疾病和肿瘤辅助治疗方面疗效显著。在总结四物汤的化学成分、药理作用及临床应用研究进展的基础上,依照中药质量标志物(Quality Marker, Q-Marker)“五原则”进行预测分析,结果提示芍药苷、芍药内酯苷、苯甲酰芍药苷、川芎嗪、阿魏酸、藁本内酯、洋川芎内酯Ⅰ、梓醇、5-羟甲基糠醛、毛蕊花糖苷可作为四物汤的Q-Marker,可选择这些Q-Marker成分作为指标对四物汤相关制剂的质量进行控制。
Siwu Decoction(四物汤)is a classic prescription for nourishing blood and replenishing blood from The Secret Formulary for Traumatology and Fracture Taught by Immortal by Taoist Lin in the Tang Dynasty,and it has the pharmacological effects of promoting bone marrow hematopoiesis,promoting erythropoiesis,repairing liver injury,estrogen-like effect,antioxidation,enhancing the ability of memory and study,improving metabolism and estrogen.It is commonly used in clinical treatment of anemia,gynecological diseases,orthopedic diseases,adjuvant treatment of tumors and other diseases.The research progress of chemical composition,pharmacological action and clinical application of Siwu Decoction in recent years were summarized,and the quality Marker(Q-Marker)of Siwu Decoction was analyzed according to the five principles of quality Markers.It was indicated that paeoniflorin,albiflorin,benzoylpaeoniflorin,tetramethylpyrazine,ferulic acid,senkyunolide I,ligustilide,catalpol,5-hydroxymethylfurfural and verbascoside can be selected as Q-Markers of Siwu Decoction.These Q-Markers components can be selected as indicators to control the quality of Siwu Decoction preparation.