文献类型：期刊文献

中文题名：基于倾向性评分匹配探索慢性萎缩性胃炎与血脂的关系

英文题名：The Exploration of the Relationship Between Chronic Atrophic Gastritis and Blood Lipids Based on Propensity Score Matching

作者：张舟[1];刘永斌[2];祁生顺[2];颉亚辉[1];吴建军[1]

第一作者：张舟

机构：[1]甘肃中医药大学公共卫生学院,甘肃兰州730000;[2]甘肃中医药大学第四附属医院体检中心,甘肃兰州730060

第一机构：甘肃中医药大学公共卫生学院

年份：2023

卷号：41

期号：2

起止页码：147

中文期刊名：中华养生保健

外文期刊名：CHINESE HEALTH CARE

基金：2022年甘肃中医药大学研究生创新创业基金(2022CX69);中国主要恶性肿瘤的危险因素监测及控制关键技术研究(31330201)。

语种：中文

中文关键词：慢性萎缩性胃炎;血脂;甘油三酯;倾向性评分匹配

外文关键词：chronic atrophic gastritis;blood lipid;triglycerides;propensity score matching

摘要：目的探索慢性萎缩性胃炎与血脂的关系。方法选取2020年1月~2022年6月在甘肃中医药大学第四附属医院体检中心完成胃镜的420例体检人群为研究对象,根据胃镜诊断结果分为慢性萎缩性胃炎339例、慢性非萎缩性胃炎81例,采用1:1倾向性评分匹配两组年龄、性别、幽门螺杆菌感染、体质量指数。匹配后数据采用两配对样本威尔科克森符号秩检验分析慢性萎缩性胃炎与血脂的关系,同时采用两独立样本曼-惠特尼U检验比较幽门螺杆菌亚组慢性萎缩性胃炎血脂水平。结果经倾向性评分匹配成功78对,匹配后组间协变量分布比较,差异均无统计学意义(P>0.05);慢性萎缩性胃炎组仅甘油三酯水平高于慢性非萎缩性胃炎组,差异有统计学意义(P<0.05);幽门螺杆菌阴性亚组慢性萎缩性胃炎组与慢性非萎缩性胃炎组甘油三酯水平比较,差异有统计学意义(P<0.05)。结论独立于幽门螺杆菌感染慢性萎缩性胃炎本身对甘油三酯水平具有显著影响,具体因果关系及机制仍需进一步探讨。
Objective To explore the relationship between chronic atrophic gastritis and blood lipid.Methods The subjects are 420 people who had the gastroscopy in the physical examination center of the Fourth Affiliated Hospital of Gansu University of Chinese Medicine in January,2020 to June,2022.According to the results of gastroscopy,they were divided into two groups:339 people had chronic atrophic gastritis in one group and 81 people had chronic non-atrophic gastritis in the other group.The age,gender,Hp infection and BMI of these people in the groups were matched with the method of 1:1PSM.The matched data was analyzed by Wilcoxon Signed Rank Test to explore the relationship between chronic atrophic gastritis and blood lipid.Meanwhile,blood lipid levels of the people with chronic gastritis were compared by Mann-Whitney U test according to Hp subgroups.Results 78 pairs were matched successfully by PS,and there was no significant difference in covariate distribution between the matched groups(P>0.05).The level of TG in chronic atrophic gastritis group was higher than that in chronic nonatrophic gastritis group(P<0.05).In the Hp negative subgroup,there was a significant difference in TG level between chronic atrophic gastritis group and chronic non-atrophic gastritis group(P<0.05).Conclusion Independent of Hp infection,chronic atrophic gastritis itself has a significant effect on TG levels,but the causal relationship needs to be further explored.