文献类型：期刊文献

中文题名：局部载药缓释系统在脊柱结核中应用的研究进展

英文题名：Research progress on application of local drug delivery and sustained-release system in spinal tuberculosis

作者：杨军[1];邓强[2];李军杰[3];王雨榕[4];杜健强[1];陈博[1];张丽娟[1]

第一作者：杨军

机构：[1]甘肃中医药大学研究生院,兰州730099;[2]甘肃省中医院医务处,兰州730050;[3]甘肃省中医院脊柱骨二科,兰州730050;[4]甘肃省中医院脊柱骨三科,兰州730050

第一机构：甘肃中医药大学党委研究生工作部、研究生院

年份：2023

卷号：45

期号：7

起止页码：707

中文期刊名：中国防痨杂志

外文期刊名：Chinese Journal of Antituberculosis

收录：CSTPCD;;CSCD:【CSCD_E2023_2024】；

基金：2021年甘肃省财政转移支付地方项目(20210140305);兰州市科技计划项目(2022-3-30)。

语种：中文

中文关键词：药物释放系统;结核,脊柱;综述文献(主题)

外文关键词：Drug delivery systems;Tuberculosis,spinal;Review literature as topic

摘要：局部载药缓释系统作为当前脊柱结核治疗新方式,已在实验阶段被发现可抑制局部结核分枝杆菌生长,利于病灶恢复,为治疗脊柱结核骨缺损提供了有效手段。现笔者对目前研究中常用的负载方式和载体材料进行综述,深入分析局部载药缓释系统作为一种新型给药策略在脊柱结核骨缺损修复中的应用价值,并对现有研究存在的挑战进行总结,以为载药缓释技术在脊柱结核外科治疗中的应用和今后的研究提供依据和方向。
As a new method for the treatment of spinal tuberculosis,the local drug delivery and sustained-release system has been found in the experimental stage to inhibit the growth of local Mycobacterium tuberculosis and facilitate lesion recovery,providing an effective means for treating bone defects caused by spinal tuberculosis.The authors reviewed relevant literature to discuss the commonly used drug loading methods and drug carrier materials in current research,deeply analyzed the application value of local drug delivery and sustained-release system as a new drug delivery strategy in the repair of spinal tuberculosis bone defects,and summarized the challenges in existing research,in order to provide a basis and direction for the application of drug delivery and sustained-release system in spinal tuberculosis surgical treatment and future research.