文献类型：期刊文献

英文题名：THE ASSOCIATION BETWEEN TUMOUR NECROSIS FACTOR-ALPHA-308G/A POLYMORPHISM AND HEPATOCELLULAR CARCINOMA RISK: AN UPDATED META-ANALYSIS

作者：Li, Zhaoxia[1,2];Zhou, Gang[3];Mi, Denghai[1,2];Ma, Bin[4];Chen, Li[5]

第一作者：Li, Zhaoxia

通信作者：Mi, DH[1]

机构：[1]Lanzhou Univ, Clin Med Coll 1, Lanzhou, Gansu, Peoples R China;[2]Second Hosp Gansu Prov, Lanzhou, Gansu, Peoples R China;[3]Hosp Gansu Prov, Lanzhou, Gansu, Peoples R China;[4]Lanzhou Univ, Sch Basic Sci, Evidence Based Med Ctr, Lanzhou, Gansu, Peoples R China;[5]Gansu Univ Tradit Chinese Med, Coll Publ Hlth, Lanzhou, Gansu, Peoples R China

第一机构：Lanzhou Univ, Clin Med Coll 1, Lanzhou, Gansu, Peoples R China

通信机构：[1]corresponding author), 222 Tianshui Rd, Lanzhou, Gansu, Peoples R China.

年份：2017

卷号：33

期号：6

起止页码：1007

外文期刊名：ACTA MEDICA MEDITERRANEA

收录：;Scopus(收录号：2-s2.0-85029226959);WOS:【SCI-EXPANDED(收录号:WOS:000411949500019)】；

基金：This work was supported by the funding plan from the Gansu province health department (grant numbers: GSWSKY-2014-14).

语种：英文

外文关键词：HCC; TNF-alpha; polymorphism; meta-analysis

摘要：Objective: To determine more precise estimations for the relationship between TNF-a-308 polymorphism and the risk for HCC through a meta-analysis of the available data. Materials and methods: We conducted a search for case-control studies on the association of TNF-a-308 polymorphism with susceptibility to HCC in PubMed, ISI Web of Science, Cochrane Central Register of Controlled Trials, Embase, Chinese Biomedical Literature Database (CBM), Chinese Journal Full-text Database (CJFD) and Wanfang Database. Odds ratios (OR) with 95% confidence intervals (95% CI) were calculated to estimate the strength of the association between TNF-a-308 polymorphism and the risk for HCC. Results: 24 studies were identified, including 4,331 HCC patients and 7,254 controls. Our results demonstrated a significant association between TNF-a-308 polymorphism and HCC risk in all genetic models while the control group was HCC-free. Howeve, when removing the data about healthy control, the pooled ORs were significantly decreased in the additive model (AA versus GG) and the allele model (G versus A), even no significant differences were observed in the rest genetic models. In an analysis stratified by ethnicity, increased risks were observed in both Asian and Caucasian populations. Conclusion: This meta-analysis suggests that TNF-a-308 GG genotype might decrease the risk of HCC development, specifically among both Asian and Caucasian populations. However, these results should be interpreted with caution because of heterogeneity of control populations. Well-designed studies with appropriate controls, larger sample sizes and more in-depth data are required to confirm this conclusion.