文献类型：期刊文献

英文题名：Does higher SBPat discharge explain better outcomes in non-heart failure with reduced ejection fraction patients? Insights fromFuwaiHospital

作者：Yao, Younan[1];Zhang, Rongcheng[1];Zhang, Qi[1];Zhao, Xinke[2];Zhang, Jian[1]

第一作者：Yao, Younan

通信作者：Zhang, J[1]

机构：[1]Chinese Acad Med Sci & Peking Union Med Coll, State Key Lab Cardiovasc Dis, Natl Ctr Cardiovasc Dis, Heart Failure Ctr,Fuwai Hosp, Beijing, Peoples R China;[2]Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou, Peoples R China

第一机构：Chinese Acad Med Sci & Peking Union Med Coll, State Key Lab Cardiovasc Dis, Natl Ctr Cardiovasc Dis, Heart Failure Ctr,Fuwai Hosp, Beijing, Peoples R China

通信机构：[1]corresponding author), Fuwai Hosp, State Key Lab Cardiovasc Dis, Heart Failure Ctr, 167 Beilishi Rd, Beijing 100037, Peoples R China.

年份：2021

卷号：39

期号：2

起止页码：356

外文期刊名：JOURNAL OF HYPERTENSION

收录：;Scopus(收录号：2-s2.0-85099324133);WOS:【SCI-EXPANDED(收录号:WOS:000612619500023)】；

基金：This study was supported by a grant for J.Z. from the Key Projects in the National Science and Technology Pillar Program of the 13th Five-Year Plan Period (NO. 2017YFC1308300), Beijing, People's Republic of China.

语种：英文

外文关键词：heart failure with mid-range ejection fraction; heart failure with preserved ejection fraction; outcome; SBP

摘要：Objective: We hypothesized that discharge SBP had different associations with outcomes in non-HFrEF (left ventricular ejection fraction >= 40%) patients with or without high blood pressure (HBP) at admission. Methods: Non-HFrEF patients hospitalized for decompensated heart failure were consecutively recruited and were categorized into HBP (admission SBP >= 130 mmHg) group and non-HBP group. The primary outcome was a composite of cardiovascular death and heart transplantation. Multivariate Cox and penalized spline analyses were used to assess the relationships between discharge SBP and outcomes. Results: Nine hundred and sixty-four non-HFrEF patients were enrolled with a median follow-up of 71.8 months. Three hundred and sixty-five (37.9%) patients had HBP. In multivariate Cox analyses, non-HBP patients with higher discharge SBP were associated with a better outcome (per 10mmHg increased, hazard ratio = 0.788, P = 0.001). However, an opposite relationship between discharge SBP and the primary outcome was observed in HBP group (per 10mmHg increased, hazard ratio = 1.312, P = 0.002). Results of penalized spline regression models showed that there was a U-shaped association between discharge SBP and outcomes in the total cohort. Compared with 120 mmHg, the risk of the primary outcome increased when discharge SBP was below 99mmHg in non-HBP group; in HBP group, a worse outcome was observed when discharged SBP was above 145 mmHg. Conclusion: Non-HFrEF had a U-shaped association between discharge SBP and adverse events. Such an association was modified by admission HBP. Higher discharge SBP correlated with a worse outcome in non-HFrEF patients with admission HBP, as opposed to patients admitted without HBP.