文献类型：期刊文献

英文题名：Research advances in capillary gel electrophoresis for detecting biomacromolecules

作者：Liu, Wen-Jing[1,2,3,4];Zhang, Ying[3,4];Li, Qiu-Yang[1,2,3,4];Li, Rui-Ting[1,2];Zhao, Long[1,2];Gatera, Tharcisse[3,4];Ma, Qu-Huan[1,2];Yang, Jun-Li[1,3,4];Shi, Xiao-Feng[1,2]

第一作者：Liu, Wen-Jing

通信作者：Ma, QH[1];Yang, JL[1];Shi, XF[1];Ma, QH[2];Shi, XF[2];Yang, JL[3];Yang, JL[4]

机构：[1]Gansu Univ Chinese Med, Coll Pharm, Lanzhou 730000, Peoples R China;[2]Gansu Prov Acad Med Sci, Inst Mat Med, Lanzhou 730000, Peoples R China;[3]Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China;[4]Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Coll Pharm, Lanzhou 730000, Peoples R China;[2]corresponding author), Gansu Prov Acad Med Sci, Inst Mat Med, Lanzhou 730000, Peoples R China;[3]corresponding author), Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China;[4]corresponding author), Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China.|[1073501e14fb35863569f]甘肃中医药大学药学院（西北中藏药协同创新中心办公室）;[10735]甘肃中医药大学;

年份：2026

卷号：1774

外文期刊名：JOURNAL OF CHROMATOGRAPHY A

收录：;EI(收录号：20261320377233);Scopus(收录号：2-s2.0-105034082234);WOS:【SCI-EXPANDED(收录号:WOS:001709387300001)】；

基金：This study was supported by the project of Noncommunicable Chronic Diseases-National Science and Technology Major Project (2030ZD0505300, 2023ZD0505305) , the project of National Key Research and Development Program of China, "Modernization of Traditional Chinese Medicine" (NO. 2024YFC3505600 & 2024YFC3505603) , the project of the National Natural Science Foundation of China (No. 22504161) , the project of Gansu Provincial Pharmaceutical Regulatory Science Research (2025GSMPA066) and project of Chengguan District Science and Technology Support Special Project (2025KJZC00066) .

语种：英文

外文关键词：Capillary gel electrophoresis; Biomacromolecules; Protein; Nucleic acid; Polysaccharides

摘要：Capillary gel electrophoresis (CGE) has been employed for the separation of biomacromolecules for over thirty years. Thanks to advances in gel materials and the ongoing development of electrophoresis instruments, the CGE method has now become one of the recognized gold standards for routine separation and analysis of biomacromolecules. This is due to its superior separation capabilities and the high robustness and reliability of its results. This paper reviews the research progress and applications of CGE in the separation and analysis of biomacromolecules, including proteins, nucleic acids, and polysaccharides, between 2015 and 2025, and offers a prospect on the future development of this technology.