文献类型：期刊文献

英文题名：High-performance electrochemical biosensor for nonenzymatic H2O2 sensing based on Au@C-Co3O4 heterostructures

作者：Dai, Hongxia[1,2,4];Chen, Yonglei[1,2];Niu, Xiaoying[1,2];Pan, Congjie[1,2];Chen, HongLi[1,2];Chen, Xingguo[1,2,3]

第一作者：Dai, Hongxia;戴红霞

通信作者：Chen, YL[1];Chen, XG[1]

机构：[1]Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China;[2]Lanzhou Univ, Dept Chem, Lanzhou 730000, Gansu, Peoples R China;[3]Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Gansu, Peoples R China;[4]Gansu Univ Chinese Med, Lanzhou 730000, Gansu, Peoples R China

第一机构：Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China.

年份：2018

卷号：118

起止页码：36

外文期刊名：BIOSENSORS & BIOELECTRONICS

收录：;EI(收录号：20183005603573);Scopus(收录号：2-s2.0-85050334918);WOS:【SCI-EXPANDED(收录号:WOS:000444358000006)】；

基金：The authors are grateful for financial support from the National Natural Science Foundation of China (No. 21675068).

语种：英文

外文关键词：Co3O4; Au nanoparticles; Nonenzymatic biosensor; Hydrogen peroxide; Living cells

摘要：An ingenious and viable method for preparing heterogeneous Co3O4 dodecahedrons that contain carbon and encapsulated Au nanoparticles (Au@C-Co3O4) was proposed via pyrolysis of Au nanoparticle-encapsulated zeolitic imidazolate framework-67 (Au@ZIF-67). The obtained Au@C-Co3O4 possessed hierarchically porous structure, abundant active sites, excellent conductivity, and durability, all of which can significantly improve the analysis performance of the biosensor. Meanwhile, the fabricated electrode based on the porous Au@C-Co3O4 showed remarkable electrocatalytic performance towards H2O2 with a limit of detection of 19 nM and ultra-high sensitivity of 7553 mu A mM(-1)cm(-2), even when the Au content in the composite was as low as 0.85 wt%. This novel biosensor was successfully used to monitor H2O2 concentration released from living cells, and the results can be used to identify cancer cells, thus advancing the use of transition metal oxides in the field of biosensing.