文献类型：期刊文献

英文题名：New insight of the pathogenesis in osteoarthritis: the intricate interplay of ferroptosis and autophagy mediated by mitophagy/chaperone-mediated autophagy

作者：An, Fangyu[1];Zhang, Jie[2];Gao, Peng[2];Xiao, Zhipan[3];Chang, Weirong[2];Song, Jiayi[2];Wang, Yujie[3];Ma, Haizhen[4];Zhang, Rui[4];Chen, Zhendong[4];Yan, Chunlu[3]

第一作者：安方玉

通信作者：Yan, CL[1]

机构：[1]Gansu Univ Chinese Med, Teaching Expt Training Ctr, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Sch Basic Med, Lanzhou, Peoples R China;[3]Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou, Peoples R China;[4]Gansu Univ Chinese Med, Teaching Dept Med, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;

年份：2023

卷号：11

外文期刊名：FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

收录：;Scopus(收录号：2-s2.0-85180421202);WOS:【SCI-EXPANDED(收录号:WOS:001128597400001)】；

基金：The authors declare that no financial support was received for the research, authorship, and/or publication of this article. This work was supported by the Young Doctor Fund Program of Colleges and Universities in Gansu Province (2022QB-091), the Scientific Research Program of Gansu Chinese Medicine Bureau (GZKP-2021-34), the Innovation Fund Project of high education institutions in Gansu province (2022A-072), and the Key Scientific Research Program of "Double first-class" in Gansu Province (No. GSSYLXM-05).

语种：英文

外文关键词：osteoarthritis; ferroptosis; mitophagy; chaperone-mediated autophagy; reactive oxygen species; adenosine monophosphate (AMP)-activated protein kinase (AMPK); hypoxia-inducible factors

摘要：Ferroptosis, characterized by iron accumulation and lipid peroxidation, is a form of iron-driven cell death. Mitophagy is a type of selective autophagy, where degradation of damaged mitochondria is the key mechanism for maintaining mitochondrial homeostasis. Additionally, Chaperone-mediated autophagy (CMA) is a biological process that transports individual cytoplasmic proteins to lysosomes for degradation through companion molecules such as heat shock proteins. Research has demonstrated the involvement of ferroptosis, mitophagy, and CMA in the pathological progression of Osteoarthritis (OA). Furthermore, research has indicated a significant correlation between alterations in the expression of reactive oxygen species (ROS), adenosine monophosphate (AMP)-activated protein kinase (AMPK), and hypoxia-inducible factors (HIFs) and the occurrence of OA, particularly in relation to ferroptosis and mitophagy. In light of these findings, our study aims to assess the regulatory functions of ferroptosis and mitophagy/CMA in the pathogenesis of OA. Additionally, we propose a mechanism of crosstalk between ferroptosis and mitophagy, while also examining potential pharmacological interventions for targeted therapy in OA. Ultimately, our research endeavors to offer novel insights and directions for the prevention and treatment of OA.