文献类型：期刊文献

中文题名：甘南藏族人群盐敏感性与代谢综合征的关系研究

英文题名：Sodium Sensitivity and Metabolic Syndrome among Tibetan Population in Gannan Tibetan Autonomous Prefecture

作者：靳利梅[1];胡继宏[1];郑贵森[1];樊景春[1];赵翊[1];陈丽[1];卓玛草[2];王建宗[3]

第一作者：靳利梅

机构：[1]甘肃中医药大学公共卫生学院,甘肃省兰州市730000;[2]甘肃省甘南藏族自治州夏河县人民医院,747100;[3]甘肃中医药大学藏医学院,甘肃省兰州市730000

第一机构：甘肃中医药大学公共卫生学院

年份：2017

卷号：20

期号：22

起止页码：2757

中文期刊名：中国全科医学

外文期刊名：Chinese General Practice

收录：CSTPCD;;Scopus;北大核心:【北大核心2014】；

基金：国家自然科学基金资助项目(81260444)

语种：中文

中文关键词：代谢综合征X;盐敏感性;高血压;藏族

外文关键词：Metabolic syndrome X; Sodium sensitivity; Hypertension; Zang nationality

摘要：目的探讨甘南藏族人群盐敏感性(SS)与代谢综合征(MS)的关系。方法于2013年6月—2014年11月,在甘肃省甘南藏族自治州夏河县和合作县选取原发性高血压病1级者737例、非高血压者631例。收集受试者的性别、年龄、身高、体质量、腰围、臀围、血压、空腹血糖(FPG)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)等临床资料,并计算BMI。采用我国改良后的急性盐负荷试验方法,根据Sullivan标准判定是否存在SS;分别根据中华医学会糖尿病学分会(CDS)、国际糖尿病联盟(IDF)、美国国家胆固醇教育计划成人治疗组第三次报告(NCEP-ATPⅢ)制定的诊断标准,判定是否患MS。结果甘南藏族高血压者、非高血压者的SS检出率分别为72.9%(537/737)、64.5%(407/631),高血压者高于非高血压者,差异有统计学意义(P<0.05)。根据CDS、IDF、NCEP-ATPⅢ诊断标准,高血压者的MS检出率分别为47.9%(353/737)、55.0%(405/737)、37.7%(278/737),非高血压者的MS检出率分别为3.5%(22/631)、15.8%(100/631)、4.8%(30/631)。是否存在SS高血压者、非高血压者根据CDS、IDF、NCEP-ATPⅢ的MS检出率比较,差异均无统计学意义(P>0.05)。SS高血压者根据CDS的BMI偏高、根据NCEP-ATPⅢ的腰围偏高检出率低于非SS高血压者,差异有统计学意义(P<0.05);SS非高血压者TG偏高、根据CDS的血糖偏高、根据IDF的血糖偏高、根据NCEP-ATPⅢ的血糖偏高检出率低于非SS非高血压者,根据IDF的腰围偏高、根据NCEP-ATPⅢ的腰围偏高检出率高于非SS非高血压者,差异有统计学意义(P<0.05)。结论甘南藏族高血压人群和非高血压人群的SS、MS检出率均较高,SS与MS间无直接关系,但MS部分组分与SS间存在统计学关联,需进一步研究证实。
Objective To investigate the relationship between sodium sensitivity（ SS） and metabolic syndrome（ MS）among Tibetan hypertensive and non-hypertensive patients in Gannan Tibetan Autonomous Prefecture.Methods A total of 737 Tibetan patients with stage 1 essential hypertension and 631 Tibetan patients without hypertension were sampled from Xiahe County and Hezuo County,Gannan Tibetan Autonomous Prefecture,Gansu Province,China between June 2013 and November2014.We obtained the clinical data of them,such as sex,age,height,weight,waist circumference,hip circumference,levels of blood pressure,fasting plasma glucose（ FPG）,triacylglycerol（ TG）,and high-density lipoprotein cholesterol（ HDL-C）,and calculated the BMI.SS was tested by using the modified Sullivan＇s acute oral salt load test.MS was diagnosed by using the diagnostic criteria developed by Chinese Diabetes Society（ CDS）,International Diabetes Federation（ IDF） and the National Cholesterol Education Program＇ s Adult Treatment Panel Ⅲ（ NCEP-ATP Ⅲ）.Results The prevalence of SS was higher in Tibetan patients with hypertension than in those without [72.9%（ 537/737） vs 64.5%（ 407/631） ],（ P 0.05）.The prevalence of MS among Tibetan patients with hypertension were 47.9%（ 353/737）,55.0%（ 405/737） and 37.7%（ 278/737）,respectively,and that among those without hypertension were 3.5%（ 22/631）,15.8%（ 100/631） and 4.8%（ 30/631）,respectively by using the CDS,IDF and the NCEP-ATPⅢ diagnostic criteria.SS was not associated with the prevalence of MS in all the participants diagnosed by the criteria of CDS,IDF and the NCEP-ATPⅢ（ P 0.05）.Higher BMI was more common in hypertensive patients with SS than in those without based on the diagnostic criteria of CDS（ P 0.05）,while increased waist circumstance was seen less frequently in hypertensive patients with SS than in those without according to the diagnostic criteria of NCEP-ATPⅢ（ P 0.05）.The prevalence of increased TG by the three kinds of diagnostic criteria,and that of increased FPG by the diagnostic criteria of CDS,and that of increased FPG by the diagnostic criteria of IDF and NCEP-ATPⅢ were all lower in Tibetan non-hypertensive patients with SS than in those without SS（ P 0.05）,while the prevalence of increased waist circumstance by the diagnostic criteria of IDF and NCEP-ATP Ⅲ was higher in Tibetan non-hypertensive patients with SS than in those without（ P 0.05）.Conclusion The prevalence of MS and SS among Tibetan hypertensive and non-hypertensive patients in Gannan Tibetan Autonomous Prefecture is high.MS is not directly associated with SS,but partial components of MS is associated with SS statistically,which needs to be investigated further.