文献类型：期刊文献

英文题名：Targeting innate immunity to modulate bone metabolism: a novel strategy for osteoporosis treatment

作者：Kou, Wenjie[1];Lu, Xiaomin[1];Zhang, Zhe[1];Liu, Kaiwen[1];Liu, Zhihuan[1];Jiang, Bin[1];Wang, Hongping[2];Li, Jishu[1];Lu, Hu[1];Guo, Chenglong[3];Cao, Linzhong[1,3];Zhang, Xiaogang[3]

第一作者：Kou, Wenjie

通信作者：Guo, CL[1]

机构：[1]Gansu Univ Tradit Chinese Med, Lanzhou, Gansu, Peoples R China;[2]Longnan Maternal & Child Hlth Hosp, Longnan, Gansu, Peoples R China;[3]Gansu Univ Tradit Chinese Med, Affiliated Hosp, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Affiliated Hosp, Lanzhou, Gansu, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2026

卷号：7

外文期刊名：FRONTIERS IN AGING

收录：WOS:【ESCI(收录号:WOS:001731984300001)】；

基金：The author(s) declared that financial support was received for this work and/or its publication. National Natural Science Foundation of China (No. 82460941); Scientific Research Project of Health Industry in Gansu Province (No. GSWSQN 2023-10); Construction Project of Zhang Xiaogang's National Famous and Veteran Traditional Chinese Medicine Expert Inheritance Studio (Letter of the State Administration of Traditional Chinese Medicine for Education and Personnel 2022 No. 75); Gansu Provincial Science and Technology Plan Project (No. 24JRRA549); Project of Gansu Administration of Traditional Chinese Medicine (No. GZKP-2022-20); Lanzhou Municipal Science and Technology Plan Project (No. 2023-2-7).

语种：英文

外文关键词：bone metabolism; complement system; innate immunity; macrophages; osteoporosis; targeted therapy; trained immunity

摘要：Osteoporosis is a systemic metabolic bone disorder characterized by reduced bone mass and impaired microarchitecture, with its core pathological mechanism being an imbalance between bone formation and resorption. Traditional therapies targeting osteoblast/osteoclast function have limited efficacy and safety concerns. Recent osteoimmunology advances reveal that the innate immune system regulates bone homeostasis via intercellular interactions, cytokine networks, and metabolic reprogramming. This systematic review examines the roles of innate immune cells (macrophages, neutrophils, NK cells, DCs), complement system, and emerging pathways (trained immunity, mitochondrial symbiosis disruption) in osteoporosis. It summarizes therapeutic strategies (immunometabolic modulators, complement antagonists, cytokine-targeted drugs, TCM components) and outlines challenges (target specificity, clinical translation) and future directions, providing theoretical foundations for novel OP treatments.