文献类型：期刊文献

中文题名：清肺通络方治疗新型冠状病毒肺炎32例临床疗效分析

英文题名：Clinical Effects of Lung-clearing Collateral-dredging Prescription in Treating 32 Cases of COVID-19

作者：周谷城[1];张志明[2];刘永琦[1,3];周婷[1];柯宜诚[1];史桐凡[1];牛帆[1];李娟[2];张利英[1,3]

第一作者：周谷城

机构：[1]甘肃中医药大学/甘肃省高校重大疾病分子医学与中医药防治研究重点实验室,甘肃兰州730000;[2]甘肃中医药大学附属医院/甘肃省中西医结合防治肿瘤临床中心;[3]甘肃中医药大学/敦煌医学与转化省部共建教育部重点实验室

第一机构：甘肃中医药大学科研实验中心（甘肃省中医药标准化技术委员会秘书处）

年份：2021

卷号：34

期号：12

起止页码：4

中文期刊名：西部中医药

外文期刊名：Western Journal of Traditional Chinese Medicine

收录：CSTPCD

基金：甘肃省新型冠状病毒肺炎(NCP)科技重大专项(2020年);甘肃省高校重大疾病分子医学与中医药防治研究重点实验室NCP防治科研专项开放基金(FZYX20-2,FZYX20-8);兰州市城关区新型冠状病毒肺炎科技专项(2020JSCX0025)。

语种：中文

中文关键词：新型冠状病毒肺炎;清肺通络方;临床疗效分析

外文关键词：COVID-19;lung-clearing collateral-dredging prescription;the analysis of clinical effects

摘要：目的:探讨清肺通络方对新型冠状病毒肺炎的治疗效果。方法:从甘肃地区91例新型冠状病毒肺炎患者中筛选出中西医结合治疗中符合使用清肺通络方的患者32例,收集患者临床症状资料、外周血白细胞、淋巴细胞、肝酶、肌酶、C反应蛋白、肺部CT、中医证型等指标,比较患者用药前后上述各指标变化。结果:32例患者中,男16例,女16例,平均年龄41岁。普通型患者19例,重型患者13例。中医证型以湿热郁肺(65.63%)、和湿温壅肺(34.38%)为主。患者治疗前的主要症状为发热(40.63%)、乏力(28.13%)、咽痛(9.38%)、咳嗽(90.63%)、咳痰(56.25%)、头晕头痛(6.25%)、胸闷气短(40.63%)、腹泻(3.13%)、食欲不振(21.88%)。使用清肺通络方后,患者咳嗽、咳痰的症状缓解率是89.66%和88.89%,其余缓解率为100%。患者治疗前主要以白细胞总数降低(46.88%)、淋巴细胞百分比降低(56.25%)、中性粒细胞百分比升高(43.75%)、淋巴细胞绝对值降低(56.25%)、C反应蛋白升高(40.63%)、血沉升高(53.13%)、乳酸脱氢酶升高(34.38%)和总胆红素升高(34.38%)为主。治疗后,咽拭子病毒核酸检测三次阴性,肺部CT示感染病灶已吸收,出院患者咳嗽、咳痰症状消失,血常规、血生化中上述异常关键指标均基本恢复正常,符合出院标准,治愈率100%,且未发生核酸检测转阳者复发病例。结论:清肺通络方可有效治疗处于疾病中期的新型冠状病毒肺炎患者。
Objective:To discuss therapeutic effects of lung-clearing collateral-dredging prescription in the treatment of COVID-19.Methods:All 32 patients who met the standard of using lung-clearing collateral-dredging prescription were screened from 91 COVID-19 patients in Gansu region,to collect TCM patterns,lung CT,CRP,muscle enzymes,liver enzymes,lymphocytes and leukocytes in peripheral blood and clinical symptoms of the patients,to compare the changes of these indexes before and after the medications.Results:Among 32 patients,there were 16 cases of male patients,and 16 cases of female patients,average age was 41 years,they contained 19 common patients and 13 severe ones.TCM patterns were damp-heat stagnating in lung(65.63%)and damp-warm obstructing lung(34.38%)mainly.The main symptoms of the patients before treating were fever(40.63%),weakness(28.13%),sore throat(9.38%),cough(90.63%),expectoration(56.25%),dizziness and headache(6.25%),chest tightness and panting(40.63%),diarrhea(3.13%)and poor appetite(21.88%).After applying lung clearing collateral-dredging prescription,cough and expectoration remission rates of the patients were 89.66%and 88.89%,the remission rate of other symptoms was 100%.Before treating,the patients manifested total number of leukocytes decreased(46.88%),decreased percentage of lymphocytes(56.25%),increased percentage of neutrophils(43.75%),the absolute value of lymphocytes decreased(56.25%),elevated CRP(40.63%),increased ESR(53.13%),lactate dehydrogenase(34.38%)and total bilirubin(34.38%)mostly.After treating,the nucleic acid test of pharyngeal swab was negative three times,pulmonary CT indicated that the infected lesion has been absorbed,cough and expectoration of the discharged patients disappeared,the abnormal indexes of routine blood test and blood chemical test returned to normal basically,which met the discharge standards,cure rate reached 100%,and no recurrent cases was found.Conclusion:Lung-clearing collateral-dredging prescription could effectively treat COVID-19 patients in the middle of the disease.