文献类型：期刊文献

中文题名：冻伤的病理机制及治疗研究进展

英文题名：Progress on the pathological mechanism and treatment of frostbite

作者：张莉[1];蔺兴遥[1,2];尚芸[1];王强[1]

第一作者：张莉

机构：[1]甘肃中医药大学,甘肃兰州730000;[2]敦煌医学与转化教育部重点实验室,甘肃兰州730000

第一机构：甘肃中医药大学

年份：2023

卷号：28

期号：3

起止页码：347

中文期刊名：中国临床药理学与治疗学

外文期刊名：Chinese Journal of Clinical Pharmacology and Therapeutics

收录：CSTPCD;;CSCD:【CSCD2023_2024】；

基金：甘肃省人才发展专项资金(40160401)。

语种：中文

中文关键词：冻伤;病理机制;治疗;研究进展

外文关键词：frostbite;pathological mechanism;treatment;research progress

摘要：冻伤是机体暴露在极端寒冷环境下而发生的组织损伤,其病理机制复杂,目前尚未完全阐明。高寒高海拔地区,户外运动者遭受损伤的风险较高,严重冻伤具有较高的致残、致死率,探究冻伤的病理机制有助于确定治疗手段和时机。目前临床治疗冻伤,以对症治疗为主,如药物治疗、手术治疗,疗效尚不能满足临床需求,因此寻求更为高效的药品或治疗手段具有重要的意义。本文综述了近年来冻伤病理生理机制、临床治疗、细胞和分子途径研究等方面的相关研究进展,以期为未来研究方向及临床治疗提供新的思路。
Frostbite is a tissue injury that occurs when the body is exposed to extreme cold.Its pathological mechanism is complex and has not been fully elucidated.In high cold and high altitude areas,outdoor sports people have a high risk of injury,and severe frostbite has high disability and mortality.Exploring the pathological mechanism of frostbite is helpful to determine the treatment methods and timing.At present,the clinical treatment of frostbite is mainly symptomatic treatment,such as drug treatment and surgical treatment,but the curative effect can not meet the clinical needs.Therefore,it is of great significance to seek more efficient drugs or treatment methods.This article reviews the relevant research progress in pathophysiological mechanism,clinical treatment,cellular and molecular pathways of frostbite in recent years,in order to provide new ideas for future research and clinical treatment.