文献类型：期刊文献

英文题名：ATP-induced cell death: a novel hypothesis for osteoporosis

作者：Wang, Wei[1];Zhang, Haolong[2];Sandai, Doblin[2];Zhao, Rui[3];Bai, Jinxia[1];Wang, Yanfei[1];Wang, Yong[4];Zhang, Zhongwen[5];Zhang, Hao-Ling[2];Song, Zhi-Jing[3]

第一作者：王薇

通信作者：Zhang, HL[1];Song, ZJ[2];Zhang, ZW[3]

机构：[1]Gansu Univ Chinese Med, Coll Acupuncture Moxibust & Tuina, Lanzhou, Gansu, Peoples R China;[2]Univ Sains Malaysia, Adv Med & Dent Inst, Dept Biomed Sci, Kepala Batas, Malaysia;[3]Gansu Univ Chinese Med, Clin Coll Chinese Med, Lanzhou, Gansu, Peoples R China;[4]Gansu Univ Chinese Med, Pathol Ctr, Lanzhou, Gansu, Peoples R China;[5]Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学针灸推拿学院

通信机构：[1]corresponding author), Univ Sains Malaysia, Adv Med & Dent Inst, Dept Biomed Sci, Kepala Batas, Malaysia;[2]corresponding author), Gansu Univ Chinese Med, Clin Coll Chinese Med, Lanzhou, Gansu, Peoples R China;[3]corresponding author), Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou, Gansu, Peoples R China.|[10735e9d5e7087247e71b]甘肃中医药大学公共卫生学院;[10735]甘肃中医药大学;

年份：2023

卷号：11

外文期刊名：FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

收录：;Scopus(收录号：2-s2.0-85180817348);WOS:【SCI-EXPANDED(收录号:WOS:001131671200001)】；

基金：No Statement Available

语种：英文

外文关键词：ATP-induced cell death; osteoporosis; bone marrow-derived mesenchymal stem cells; osteoblasts; osteoclasts; complications; apoptosis; autophagy

摘要：ATP-induced cell death has emerged as a captivating realm of inquiry with profound ramifications in the context of osteoporosis. This study unveils a paradigm-shifting hypothesis that illuminates the prospective involvement of ATP-induced cellular demise in the etiology of osteoporosis. Initially, we explicate the morphological attributes of ATP-induced cell death and delve into the intricacies of the molecular machinery and regulatory networks governing ATP homeostasis and ATP-induced cell death. Subsequently, our focus pivots towards the multifaceted interplay between ATP-induced cellular demise and pivotal cellular protagonists, such as bone marrow-derived mesenchymal stem cells, osteoblasts, and osteoclasts, accentuating their potential contributions to secondary osteoporosis phenotypes, encompassing diabetic osteoporosis, glucocorticoid-induced osteoporosis, and postmenopausal osteoporosis. Furthermore, we probe the captivating interplay between ATP-induced cellular demise and alternative modalities of cellular demise, encompassing apoptosis, autophagy, and necroptosis. Through an all-encompassing inquiry into the intricate nexus connecting ATP-induced cellular demise and osteoporosis, our primary goal is to deepen our comprehension of the underlying mechanisms propelling this malady and establish a theoretical bedrock to underpin the development of pioneering therapeutic strategies.