文献类型：期刊文献

中文题名：甘肃不同产地黄芩茎叶的抗炎作用研究

英文题名：Anti-inflammatory effect on stems and leaves of Scutellaria baicalensis from different areas of Gansu Province

作者：杨志军[1,2];李晶[1];杨秀娟[1];耿广琴[1];邓毅[1,2]

第一作者：杨志军

机构：[1]甘肃中医学院,兰州730000;[2]甘肃省中药药理与毒理学重点实验室,兰州730000

第一机构：甘肃中医药大学

年份：2015

卷号：31

期号：1

起止页码：153

中文期刊名：中药药理与临床

外文期刊名：Pharmacology and Clinics of Chinese Materia Medica

收录：北大核心:【北大核心2014】；CSCD:【CSCD2015_2016】；

基金：甘肃省高校基本科研业务费项目(编号BH2012-020)

语种：中文

中文关键词：黄芩茎叶;抗炎作用;产地

外文关键词：Stems and leaves of Scutellaria baicalensis（黄芩茎叶） ; anti-inflammatory

摘要：目的:研究甘肃不同产地黄芩茎叶水煎液的抗炎作用。方法:采用1%角叉菜胶建立大鼠足肿胀模型、2%角叉菜胶建立大鼠胸膜炎模型,观察甘肃不同产地黄芩茎叶水煎液的抗炎活性。检测模型大鼠的足肿胀度及肿胀足中前列腺素E2(PGE2)含量,检测胸膜炎大鼠血清中一氧化氮(NO)及肿瘤坏死因子α(TNF-α)含量,探讨其抗炎作用。结果:致炎3h和4h时,不同产地黄芩茎叶水煎液(6g/kg)均能显著降低大鼠足肿胀度,均能降低大鼠足组织PGE2含量,其中漳县和陇西产黄芩茎叶的作用较强;不同产地黄芩茎叶水煎液(6g/kg)均能显著降低胸膜炎大鼠血清NO和TNF-α含量;其中其中漳县和陇西产黄芩茎叶的作用较强。结论:甘肃不同产地黄芩茎叶均有显著的抗炎作用,其中甘肃陇西、漳县产黄芩茎叶抗炎作用较优。
Objective： To study the anti-inflammatory effects on stems and leaves of Scutellaria baicalensis from different areas of Gansu Province.Methods： Paw edema model and pleurisy model induced by carrageenan in rats were used for anti-inflammatory experiments. Paw swelling degrees and prostaglandin E2（ PGE2） content in footpad were determined,and the content of nitric oxide（ NO） and tumor necrosis factor alpha（ TNF-α） in serum of pleurisy rats were measured to explore the anti-inflammatory effect. Results： After given with stems and leaves of Scutellaria baicalensis decoction by intragastric administration（ 6g / kg）,the rat paw swellings were reduced at 3h or 4h（ P〈0. 05）,and the content of PGE2 in rat paw tissue was decreased（ P〈0. 05）,The NO and TNF-α content in serum were significantly reduced the pleurisy rats（ P〈0. 05）,the effects of production of Zhangxian and Longxi are stronger（ P〈0. 05）. Conclusion： There was a significant anti-inflammation activity on stems and leaves of Scutellaria baicalensis in different areas of Gansu Province,The anti-inflammatory effect of productions from Longxi and Zhangxian are better.