文献类型：期刊文献

英文题名：Sedative and hypnotic effect of freeze-dried paeoniflorin and Sini San freeze-dried powder in pentobarbital sodium-induced mice

作者：Li, Yuefeng[1];Wu, Pingan[2];Ning, Yanmei[2];Yan, Xingke[2];Zhu, Tiantian[2];Ma, Chongbing[2];Liu, Anguo[2]

第一作者：李越峰

通信作者：Yan, XK[1]

机构：[1]Gansu Univ Chinese Med, Gansu Coll Tradit Chinese Med, Dept Pharm, Key Lab Pharmacol & Toxicol Tradit Chinese Med Ga, Lanzhou 730020, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Dept Acupuncture, Lanzhou 730020, Peoples R China

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）|甘肃中医药大学科研实验中心（甘肃省中医药标准化技术委员会秘书处）

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Dept Acupuncture, Lanzhou 730020, Peoples R China.|[10735]甘肃中医药大学;

年份：2014

卷号：34

期号：2

起止页码：184

外文期刊名：JOURNAL OF TRADITIONAL CHINESE MEDICINE

收录：;Scopus(收录号：2-s2.0-84899669549);WOS:【SCI-EXPANDED(收录号:WOS:000334563800011)】；

基金：Supported by Gansu Province Finance colleges Fundamental Research Foundation (No. 2013-2); Ministry of Education, Science and Technology Key Project (No. 212186); and Gansu Province Natural Science Foundation (No. 1010RJZA212)

语种：英文

外文关键词：Paeoniflorin; Pentobarbital; Hypnotics and sedatives; Sleep; Sini San

摘要：OBJECTIVE: To investigate the sedative and hypnotic activity of paeoniflorin and freeze-dried Sini San powder on mice and provide a reliable method for determining the pharnnacodynamic material basis of Sini San. METHODS: Male adult mice weighing 20-22 g were used in this study. Three experiments were carried out. Synergism with pentobarbital was used as an index for hypnotic effect. Loss of the righting reflex was used to determine the start of sleep. Sleep latency and sleeping time were recorded in each experiment. RESULTS: The coefficient of variation of the suprathreshold dose (55 mg/kg) was significantly lower than that of the threshold dose. The sleep latency of mice was significantly decreased, and the sleeping time of mice was significantly prolonged. The effects of paeoniflorin and Sini San on prolonging the sleeping time of mice induced by pentobarbital sodium were significantly stronger than those in the control group. CONCLUSION: Paeoniflorin produces significant sedative and hypnotic effects, and there is an obvious dose-effect relationship. (C) 2014 JTCM. All rights reserved.